DegronMD - Q96NM4(TOX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E210D	TCGA-21-1082	LUSC	TCGA	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.2778
p.S206Y	TCGA-77-8144	LUSC	TCGA	PSSST	DEG_SPOP_SBC_1	212:216	Mutation substituting flanking lysine	0.2778
p.S212L	TCGA-BR-8680	STAD	TCGA	PSSST	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.7667
p.S205R	TCGA-E2-A576	BRCA	TCGA	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.T207I	TCGA-EY-A215	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1944
p.P203L	TCGA-GN-A8LK	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0833
p.P203R	TCGA-YD-A9TA	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0833
p.R216S	DO44299	CESC	ICGC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.7427
p.A220T	DO10373	COAD	ICGC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.2222
p.A221T	DO10332	COAD	ICGC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1944
p.N202S	DO234441	ESAD	ICGC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0556
p.G224V	DO229036	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1111
p.G224S	DO222743	MELA	ICGC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1111
p.K206E	DO51965	PRAD	ICGC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation substituting flanking lysine	0.2778
p.E203K	DO37946	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0833
p.K217E	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.3056
p.K217E	ACH-000981	Leukemia	CCLE	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.3056
p.K217E	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.3056
p.R223K	SIDM00358	Gastric Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.R223K	ACH-000144	Gastric Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.R223K	RERF-GC-1B	stomach	COSMIC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.S205G	G-MEL	skin	COSMIC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.A212T	23132-87	stomach	COSMIC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.7139
p.A208V	D-502MG	central nervous system	COSMIC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.2222
p.R216K	MZ7-mel	skin	COSMIC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.7237
p.K226E	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	212:216	Mutation substituting flanking lysine	0.1667

Kaplan plot for TOX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOX2

UniProt ID: Q96NM4

Entrez ID: 84969

Protein name: TOX high mobility group box family member 2 (Granulosa cell HMG box protein 1) (GCX-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOX2 in