DegronMD - Q96NW4(ANKRD27)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V677F	TCGA-DD-AAE2	LIHC	TCGA	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.V677F	DO52256	LIHC	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.S658L	TCGA-K4-A3WS	BLCA	TCGA	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.1111
p.S658L	DO480	BLCA	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.1111
p.S657G	DO228483	BRCA	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.S657G	DO222840	COCA	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.S657G	DO229016	COCA	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.S657G	DO229005	COCA	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.S657G	DO228947	LICA	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.S657G	DO230522	LUSC	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.S657G	DO230535	LUSC	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.S657G	DO230530	LUSC	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.S657G	DO231056	LUSC	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.0833
p.A676V	DO229054	LICA	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.1111
p.L673F	DO229054	LICA	ICGC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.1944
p.K665M	SIDM01095	Rhabdomyosarcoma	GDSC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.3056
p.K665M	ACH-000833	Sarcoma	CCLE	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.3056
p.K665M	SJRH30	soft tissue	COSMIC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.3056
p.V670L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.2778
p.V670L	HARA	lung	COSMIC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.2778
p.L673I	SIDM00502	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.1944
p.L673I	ACH-000157	Lymphoma	CCLE	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.1944
p.L673I	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.1944
p.R675K	SIDM00918	Ovarian Carcinoma	GDSC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.1389
p.R675K	Caov-4	ovary	COSMIC	DYR	CBL_MET	666:668	Mutation rewiring degron network	0.1389

Kaplan plot for ANKRD27 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD27

UniProt ID: Q96NW4

Entrez ID: 84079

Protein name: Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD27 in