DegronMD - Q96NY7(CLIC6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H545R	TCGA-23-2643	OV	TCGA	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1111
p.H545R	DO28008	OV	ICGC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1111
p.A561V	TCGA-A3-A8OW	KIRC	TCGA	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1944
p.A561V	TCGA-AP-A056	UCEC	TCGA	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1944
p.A561V	DO219233	KIRC	ICGC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1944
p.A561V	DO43971	UCEC	ICGC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1944
p.A561V	ACH-000967	Colon/Colorectal Cancer	CCLE	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1944
p.A561V	ACH-001199	Colon/Colorectal Cancer	CCLE	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1944
p.A561V	SNU-C2B	large intestine	COSMIC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1944
p.F559L	TCGA-AJ-A5DW	UCEC	TCGA	PPRY	ITCH	553:556	Mutation rewiring degron network	0.25
p.F559L	DO50075	UCEC	ICGC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.25
p.V555M	TCGA-AP-A059	UCEC	TCGA	PPRY	ITCH	553:556	Mutation altering degron motif	0.7208
p.V555M	DO41361	UCEC	ICGC	PPRY	ITCH	553:556	Mutation altering degron motif	0.7208
p.T566M	TCGA-B0-5400	KIRC	TCGA	PPRY	ITCH	553:556	Mutation rewiring degron network	0.0556
p.T566M	DO19308	KIRC	ICGC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.0556
p.S550C	TCGA-B0-5695	KIRC	TCGA	PPRY	ITCH	553:556	Mutation substituting flanking lysine	0.3611
p.S550C	DO17054	KIRC	ICGC	PPRY	ITCH	553:556	Mutation substituting flanking lysine	0.3611
p.E547K	TCGA-BS-A0UV	UCEC	TCGA	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1667
p.E547K	DO42793	UCEC	ICGC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1667
p.E547K	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1667
p.A551T	TCGA-CM-6171	COAD	TCGA	PPRY	ITCH	553:556	Mutation rewiring degron network	0.2778
p.A551T	DO8151	COAD	ICGC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.2778
p.P546S	TCGA-EE-A2MF	SKCM	TCGA	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1389
p.P546S	DO222491	MELA	ICGC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1389
p.P546S	DO51249	SKCM	ICGC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1389
p.A561T	DO225334	BRCA	ICGC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1944
p.P564L	SIDM00648	Small Cell Lung Carcinoma	GDSC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1111
p.P564L	SIDM01629	Melanoma	GDSC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1111
p.E565K	SIDM01588	Endometrial Carcinoma	GDSC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.0833
p.F562L	ACH-000656	Lymphoma	CCLE	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1667
p.F562L	SU-DHL-8	NS	COSMIC	PPRY	ITCH	553:556	Mutation rewiring degron network	0.1667

Kaplan plot for CLIC6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLIC6

UniProt ID: Q96NY7

Entrez ID: 54102

Protein name: Chloride intracellular channel protein 6 (Parchorin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLIC6 in