DegronMD - Q96P26(NT5C1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S140N	TCGA-A5-A1OF	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	148:152	Mutation blocking phosphorylation signal	0.5556
p.P161S	TCGA-DA-A1I2	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.A145D	TCGA-EO-A22X	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.E151D	DO219030	BLCA	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.6758
p.R162W	DO227944	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.R162Q	DO227976	COCA	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.N152S	DO15919	HNSC	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7069
p.A157T	DO229053	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1944
p.G159A	DO231518	LINC	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1389
p.R144Q	DO23735	LUAD	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.R162L	DO37782	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.E151K	DO47706	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7022
p.D140N	DO219503	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation blocking phosphorylation signal	0.5556
p.R144W	DO50130	STAD	ICGC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.T152M	SIDM00373	Endometrial Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.8534
p.T152M	SNG-M	endometrium	COSMIC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.8534
p.A145V	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.A145V	NCI-H661	lung	COSMIC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.R155W	SIDM01770	Gastric Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.I160S	SNU-81	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111

Kaplan plot for NT5C1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NT5C1B

UniProt ID: Q96P26

Entrez ID: 100526794

Protein name: Cytosolic 5'-nucleotidase 1B (cN1B) (EC 3.1.3.5) (Autoimmune infertility-related protein) (Cytosolic 5'-nucleotidase IB) (cN-IB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NT5C1B in