DegronMD - Q96PK6(RBM14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R636C	TCGA-97-8174	LUAD	TCGA	DYR	CBL_MET	634:636	Mutation altering degron motif	0.8301
p.R636C	DO25199	LUAD	ICGC	DYR	CBL_MET	634:636	Mutation altering degron motif	0.8301
p.R585Q	TCGA-AR-A24V	BRCA	TCGA	PPPY	ITCH	573:576	Mutation rewiring degron network	0.0833
p.R585Q	TCGA-D1-A16F	UCEC	TCGA	PPPY	ITCH	573:576	Mutation rewiring degron network	0.0833
p.R585Q	DO2848	BRCA	ICGC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.0833
p.R585Q	DO42408	UCEC	ICGC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.0833
p.R585Q	SIDM00251	Gastric Carcinoma	GDSC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.0833
p.R585Q	ACH-000949	Gastric Cancer	CCLE	PPPY	ITCH	573:576	Mutation rewiring degron network	0.0833
p.R585Q	TGBC11TKB	stomach	COSMIC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.0833
p.R625C	TCGA-AX-A2HD	UCEC	TCGA	DYR	CBL_MET	613:615	Mutation rewiring degron network	0.0556
p.R625C	TCGA-AX-A2HD	UCEC	TCGA	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.0833
p.R625C	DO42608	UCEC	ICGC	DYR	CBL_MET	613:615	Mutation rewiring degron network	0.0556
p.R625C	DO42608	UCEC	ICGC	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.0833
p.G564E	TCGA-B5-A0K2	UCEC	TCGA	PPPY	ITCH	573:576	Mutation rewiring degron network	0.0833
p.G564E	DO43835	UCEC	ICGC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.0833
p.R607H	TCGA-B5-A3FC	UCEC	TCGA	DYR	CBL_MET	613:615	Mutation rewiring degron network	0.1667
p.R607H	DO41871	UCEC	ICGC	DYR	CBL_MET	613:615	Mutation rewiring degron network	0.1667
p.P574L	TCGA-BR-4292	STAD	TCGA	PPPY	ITCH	573:576	Mutation altering degron motif	0.7582
p.P574L	DO38495	STAD	ICGC	PPPY	ITCH	573:576	Mutation altering degron motif	0.7582
p.R578H	TCGA-D1-A103	UCEC	TCGA	PPPY	ITCH	573:576	Mutation rewiring degron network	0.2778
p.R578H	DO42312	UCEC	ICGC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.2778
p.R637C	TCGA-E6-A1LX	UCEC	TCGA	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.3056
p.R637C	DO41020	UCEC	ICGC	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.3056
p.Y645H	TCGA-E7-A6MD	BLCA	TCGA	DYR	CBL_MET	634:636	Mutation blocking phosphorylation signal	0.5278
p.Y645H	DO219015	BLCA	ICGC	DYR	CBL_MET	634:636	Mutation blocking phosphorylation signal	0.5278
p.R626H	TCGA-EC-A1QX	UCEC	TCGA	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.1111
p.R626H	DO42592	UCEC	ICGC	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.1111
p.R626H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.1111
p.R626H	ACH-000938	Leukemia	CCLE	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.1111
p.R626H	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.1111
p.S623L	TCGA-EE-A2GJ	SKCM	TCGA	DYR	CBL_MET	613:615	Mutation blocking phosphorylation signal	0.5556
p.S623L	DO37746	SKCM	ICGC	DYR	CBL_MET	613:615	Mutation blocking phosphorylation signal	0.5556
p.S604F	TCGA-EE-A3AC	SKCM	TCGA	DYR	CBL_MET	613:615	Mutation rewiring degron network	0.0833
p.S604F	DO37631	SKCM	ICGC	DYR	CBL_MET	613:615	Mutation rewiring degron network	0.0833
p.P573Q	TCGA-HE-7128	KIRP	TCGA	PPPY	ITCH	573:576	Mutation altering degron motif	0.7035
p.P573Q	DO20796	KIRP	ICGC	PPPY	ITCH	573:576	Mutation altering degron motif	0.7035
p.R607S	TCGA-KD-A5QU	SARC	TCGA	DYR	CBL_MET	613:615	Mutation rewiring degron network	0.1667
p.R607S	DO223272	SARC	ICGC	DYR	CBL_MET	613:615	Mutation rewiring degron network	0.1667
p.R580H	TCGA-XK-AAIW	PRAD	TCGA	PPPY	ITCH	573:576	Mutation rewiring degron network	0.2222
p.R580H	DO51407	PRAD	ICGC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.2222
p.T579P	DO222534	BTCA	ICGC	PPPY	ITCH	573:576	Mutation blocking phosphorylation signal	0.6944
p.Y614C	DO230309	COCA	ICGC	DYR	CBL_MET	613:615	Mutation altering degron motif	0.8198
p.A567V	DO36556	READ	ICGC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.1667
p.P584L	SIDM01196	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.1111
p.P584L	ACH-000422	Liver Cancer	CCLE	PPPY	ITCH	573:576	Mutation rewiring degron network	0.1111
p.P584L	SNU-475	liver	COSMIC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.1111
p.P639S	SIDM00217	Colorectal Carcinoma	GDSC	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.25
p.P639S	ACH-000999	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.25
p.P639S	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	634:636	Mutation rewiring degron network	0.25

Kaplan plot for RBM14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM14

UniProt ID: Q96PK6

Entrez ID: 100526737

Protein name: RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM14 in