DegronMD - Q96PN7(TRERF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A675V	TCGA-A5-A0GI	UCEC	TCGA	PPSY	ITCH	666:669	Mutation rewiring degron network	0.1667
p.P666L	TCGA-AY-A54L	COAD	TCGA	PPSY	ITCH	666:669	Mutation altering degron motif	0.7582
p.P666L	TCGA-BG-A0MK	UCEC	TCGA	PPSY	ITCH	666:669	Mutation altering degron motif	0.7582
p.P666L	TCGA-IN-8462	STAD	TCGA	PPSY	ITCH	666:669	Mutation altering degron motif	0.7582
p.Q343H	TCGA-B5-A3FA	UCEC	TCGA	PPSY	ITCH	348:351	Mutation rewiring degron network	0.1944
p.Q343H	DO52402	UCEC	ICGC	PPSY	ITCH	348:351	Mutation rewiring degron network	0.1944
p.S678L	TCGA-BF-A5EQ	SKCM	TCGA	PPSY	ITCH	666:669	Mutation rewiring degron network	0.0833
p.S678L	TCGA-BK-A6W3	UCEC	TCGA	PPSY	ITCH	666:669	Mutation rewiring degron network	0.0833
p.S678L	DO219452	SKCM	ICGC	PPSY	ITCH	666:669	Mutation rewiring degron network	0.0833
p.S678L	DO50076	UCEC	ICGC	PPSY	ITCH	666:669	Mutation rewiring degron network	0.0833
p.P671S	TCGA-D3-A8GI	SKCM	TCGA	PPSY	ITCH	666:669	Mutation rewiring degron network	0.2778
p.N670S	TCGA-DI-A1BU	UCEC	TCGA	PPSY	ITCH	666:669	Mutation rewiring degron network	0.3056
p.L661F	TCGA-EE-A29T	SKCM	TCGA	PPSY	ITCH	666:669	Mutation rewiring degron network	0.1944
p.L661F	DO37742	SKCM	ICGC	PPSY	ITCH	666:669	Mutation rewiring degron network	0.1944
p.R657W	TCGA-FW-A3R5	SKCM	TCGA	PPSY	ITCH	666:669	Mutation rewiring degron network	0.0833
p.R353S	DO222840	COCA	ICGC	PPSY	ITCH	348:351	Mutation rewiring degron network	0.2778
p.R677W	DO37406	SKCM	ICGC	PPSY	ITCH	666:669	Mutation rewiring degron network	0.1111
p.S350P	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	348:351	Mutation altering degron motif	0.5641
p.S350P	REH	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	348:351	Mutation altering degron motif	0.5641
p.Q669R	SIDM01201	Other Blood Cancers	GDSC	PPSY	ITCH	666:669	Mutation altering degron motif	0.7329
p.Q669R	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	666:669	Mutation altering degron motif	0.7329
p.A674T	ACH-000879	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	666:669	Mutation rewiring degron network	0.1944
p.A674T	MFE-296	endometrium	COSMIC	PPSY	ITCH	666:669	Mutation rewiring degron network	0.1944
p.P667S	ACH-000963	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	666:669	Mutation altering degron motif	0.6752
p.P667S	CCK-81	large intestine	COSMIC	PPSY	ITCH	666:669	Mutation altering degron motif	0.6752
p.S675N	NCI-H1651	lung	COSMIC	PPSY	ITCH	666:669	Mutation rewiring degron network	0.1667
p.F345S	HT-115	large intestine	COSMIC	PPSY	ITCH	348:351	Mutation rewiring degron network	0.25
p.K350N	CW-2	large intestine	COSMIC	PPSY	ITCH	348:351	Mutation altering degron motif	0.6918

Kaplan plot for TRERF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRERF1

UniProt ID: Q96PN7

Entrez ID: 55809

Protein name: Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRERF1 in