DegronMD - Q96PY5(FMNL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G599R	TCGA-DX-AB2F	SARC	TCGA	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation altering degron motif	0.6457
p.G599R	TCGA-FW-A3R5	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation altering degron motif	0.6457
p.G599R	DO220075	SARC	ICGC	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation altering degron motif	0.6457
p.G599R	DO37406	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation altering degron motif	0.6457
p.G599E	TCGA-DX-AB2F	SARC	TCGA	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation altering degron motif	0.6087
p.G599E	DO220075	SARC	ICGC	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation altering degron motif	0.6087
p.V606A	TCGA-HU-A4GX	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation rewiring degron network	0.2222
p.V606A	DO47757	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation rewiring degron network	0.2222
p.V606F	DO229018	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation rewiring degron network	0.2222
p.P590L	SIDM00684	Glioblastoma	GDSC	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation rewiring degron network	0.1111
p.P590L	ACH-000595	Brain Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation rewiring degron network	0.1111
p.P590L	LN-229	central nervous system	COSMIC	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation rewiring degron network	0.1111
p.S602L	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation altering degron motif	0.7667
p.S602L	ACH-000904	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation altering degron motif	0.7667
p.S602L	ACH-001362	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation altering degron motif	0.7667
p.S602L	NCI-H1770	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation altering degron motif	0.7667
p.L591I	ACH-000941	Endometrial/Uterine Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	598:602	Mutation rewiring degron network	0.1389

Kaplan plot for FMNL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FMNL2

UniProt ID: Q96PY5

Entrez ID: 114793

Protein name: Formin-like protein 2 (Formin homology 2 domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FMNL2 in