DegronMD - Q96Q89(KIF20B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K1594R	TCGA-19-5956	GBM	TCGA	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.1667
p.K1594R	DO13863	GBM	ICGC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.1667
p.R1577Q	TCGA-AP-A0LM	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.1389
p.R1577Q	TCGA-E6-A1LX	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.1389
p.R1577Q	DO43306	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.1389
p.R1577Q	DO41020	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.1389
p.I1585V	TCGA-FV-A3I1	LIHC	TCGA	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation altering degron motif	0.7076
p.I1585V	DO22914	LIHC	ICGC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation altering degron motif	0.7076
p.E1576K	DO52057	HNSC	ICGC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.1111
p.P1579S	DO220884	MELA	ICGC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation substituting flanking lysine	0.3056
p.P1579S	DO218849	SKCA	ICGC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation substituting flanking lysine	0.3056
p.F1589Y	SIDM00202	Ewing's Sarcoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.3056
p.F1589Y	SIDM00346	Chronic Myelogenous Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.3056
p.F1589Y	SIDM00462	Acute Myeloid Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.3056
p.F1589Y	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.3056
p.F1589Y	SIDM00783	Colorectal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.3056
p.F1589Y	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.3056
p.F1589Y	SIDM01699	Chondrosarcoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.3056
p.P1592S	ACH-000999	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.2222
p.P1592S	SNU-1040	large intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.2222
p.Q1574R	TOV-21G	ovary	COSMIC	PLSTS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.0556

Kaplan plot for KIF20B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF20B

UniProt ID: Q96Q89

Entrez ID: 9585

Protein name: Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF20B in