GCNA
UniProt ID: Q96QF7
Entrez ID: 93953
Protein name: Germ cell nuclear acidic protein (Acidic repeat-containing protein) (Germ cell nuclear acidic peptidase) (Germ cell nuclear antigen)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:30914427). Can resolve the topoisomerase II (TOP2A) DPCs (By s...
FUNCTION: May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:30914427). Can resolve the topoisomerase II (TOP2A) DPCs (By similarity). {ECO:0000250|UniProtKB:A0A1D9BZF0, ECO:0000269|PubMed:30914427}.
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GO - Biological processes (BP):
protein-DNA covalent cross-linking repair [GO:0106300]...
protein-DNA covalent cross-linking repair [GO:0106300]
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GO - Molecular function (MF):
SUMO polymer binding [GO:0032184]...
SUMO polymer binding [GO:0032184]
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GO - Cellular component (CC):
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]...
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]
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GCNA
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*NOTE: the Kaplan plots were collected from OncoLnc