DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
FRG2B
UniProt ID:
Q96QU4
Entrez ID:
441581
Protein name:
Protein FRG2-like-1 (FSHD region gene 2 protein family member B) (HSA10-FRG2)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
nucleus [GO:0005634]...
nucleus [GO:0005634]
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
FRG2B
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TCGA
ICGC
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CCLE
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Show Degron:
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Phosphorylation
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.R58M
TCGA-DF-A2KN
UCEC
TCGA
NKENS
DEG_APCC_KENBOX_2
66:70
Mutation rewiring degron network
0.1111
p.R58M
DO223282
UCEC
ICGC
NKENS
DEG_APCC_KENBOX_2
66:70
Mutation rewiring degron network
0.1111
p.N94Y
TCGA-EO-A22R
UCEC
TCGA
PESSS
DEG_SPOP_SBC_1
86:90
Mutation rewiring degron network
0.2222
p.I56T
DO228950
LICA
ICGC
NKENS
DEG_APCC_KENBOX_2
66:70
Mutation rewiring degron network
0.0556
p.S81R
DO52363
LUSC
ICGC
PESSS
DEG_SPOP_SBC_1
86:90
Mutation rewiring degron network
0.1944
p.S81R
DO229173
THCA
ICGC
PESSS
DEG_SPOP_SBC_1
86:90
Mutation rewiring degron network
0.1944
p.S81R
DO229204
THCA
ICGC
PESSS
DEG_SPOP_SBC_1
86:90
Mutation rewiring degron network
0.1944
p.S81R
DO229250
THCA
ICGC
PESSS
DEG_SPOP_SBC_1
86:90
Mutation rewiring degron network
0.1944
p.S81R
DO229084
THCA
ICGC
PESSS
DEG_SPOP_SBC_1
86:90
Mutation rewiring degron network
0.1944
p.G79W
DO229218
THCA
ICGC
NKENS
DEG_APCC_KENBOX_2
66:70
Mutation rewiring degron network
0.0833
p.G79W
DO229218
THCA
ICGC
PESSS
DEG_SPOP_SBC_1
86:90
Mutation rewiring degron network
0.1389
p.S62W
DO229250
THCA
ICGC
NKENS
DEG_APCC_KENBOX_2
66:70
Mutation rewiring degron network
0.2222
p.N95Y
DO42713
UCEC
ICGC
PESSS
DEG_SPOP_SBC_1
86:90
Mutation rewiring degron network
0.1944
p.G83R
ACH-000960
Leukemia
CCLE
PESSS
DEG_SPOP_SBC_1
86:90
Mutation rewiring degron network
0.25
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for FRG2B in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc