DegronMD - Q96RT1(ERBIN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I979T	SIDM00466	Ovarian Carcinoma	GDSC	PPQY	ITCH	974:977	Mutation rewiring degron network	0.2778
p.I979T	OVKATE	ovary	COSMIC	PPQY	ITCH	974:977	Mutation rewiring degron network	0.2778
p.S984T	SIDM00797	Melanoma	GDSC	PPQY	ITCH	974:977	Mutation blocking phosphorylation signal	0.5833
p.S984T	A2058	skin	COSMIC	PPQY	ITCH	974:977	Mutation blocking phosphorylation signal	0.5833
p.Y977F	SIDM00965	Small Cell Lung Carcinoma	GDSC	PPQY	ITCH	974:977	Mutation altering degron motif	0.8639
p.Y977F	NCI-H446	lung	COSMIC	PPQY	ITCH	974:977	Mutation altering degron motif	0.8639
p.N1224H	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	1214:1218	Mutation rewiring degron network	0.1667
p.N1224H	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	1214:1218	Mutation rewiring degron network	0.1667
p.Q1221R	RCC-JW	kidney	COSMIC	PQTSS	DEG_SPOP_SBC_1	1214:1218	Mutation rewiring degron network	0.25
p.I1228T	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	1214:1218	Mutation rewiring degron network	0.0556
p.I1228T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	1214:1218	Mutation rewiring degron network	0.0556
p.N1228H	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	1214:1218	Mutation rewiring degron network	0.0556
p.N1228H	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	1214:1218	Mutation rewiring degron network	0.0556
p.S980T	A2058	skin	COSMIC	PPQY	ITCH	974:977	Mutation rewiring degron network	0.25
p.I975T	OVKATE	ovary	COSMIC	PPQY	ITCH	974:977	Mutation altering degron motif	0.7078
p.Q1217R	RCC-JW	kidney	COSMIC	PQTSS	DEG_SPOP_SBC_1	1214:1218	Mutation altering degron motif	0.7329
p.Y973F	NCI-H446	lung	COSMIC	PPQY	ITCH	974:977	Mutation rewiring degron network	0.3056

Kaplan plot for ERBIN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERBIN

UniProt ID: Q96RT1

Entrez ID: 55914

Protein name: Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERBIN in