DegronMD - Q96RU2(USP28)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P510S	TCGA-B5-A3FC	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.R519W	TCGA-D7-A6EV	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.3056
p.D507N	TCGA-EO-A22X	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.M522I	TCGA-FS-A1ZG	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.M522I	ACH-000458	Skin Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.S508F	TCGA-WE-A8K5	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.T521A	DO3686	BRCA	ICGC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation blocking phosphorylation signal	0.6944
p.T521A	Ca-Ski	cervix	COSMIC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation blocking phosphorylation signal	0.6944
p.V506G	DO222364	BTCA	ICGC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1111
p.R516G	DO223703	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7568
p.R516G	DO40978	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7568
p.R520Q	DO9876	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation blocking phosphorylation signal	0.7222
p.R520Q	COLO-800	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation blocking phosphorylation signal	0.7222
p.V517A	DO222790	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.6936
p.D528Y	DO23952	LUAD	ICGC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0556
p.Y507C	DO51474	PACA	ICGC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.P514L	DO223910	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7582
p.R519Q	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.3056
p.R519Q	ACH-000938	Leukemia	CCLE	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.3056
p.R519Q	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.3056
p.P528T	SIDM00807	Bladder Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0556
p.P528T	ACH-000905	Bladder Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0556
p.P528T	5637	urinary tract	COSMIC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0556
p.A527T	ESS-1	endometrium	COSMIC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0833
p.A513T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation blocking ubiquitination signal	0.75
p.A527S	CAL-54	kidney	COSMIC	PLTSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0833

Kaplan plot for USP28 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP28

UniProt ID: Q96RU2

Entrez ID: 57646

Protein name: Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP28 in