DegronMD - Q96RV3(PCNX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K558E	SIDM00001	Other Blood Cancers	GDSC	PKSSS	DEG_SPOP_SBC_1	544:548	Mutation substituting flanking lysine	0.1667
p.S2193C	SIDM01126	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	2191:2195	Mutation altering degron motif	0.7541
p.S2193C	NCI-H64	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	2191:2195	Mutation altering degron motif	0.7541
p.I1993V	SIDM00472	Ovarian Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	1997:2001	Mutation rewiring degron network	0.2222
p.I1993V	PEO1	ovary	COSMIC	PLTTS	DEG_SPOP_SBC_1	1997:2001	Mutation rewiring degron network	0.2222
p.E2007K	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	1997:2001	Mutation rewiring degron network	0.1667
p.E2007K	SK-LU-1	lung	COSMIC	PLTTS	DEG_SPOP_SBC_1	1997:2001	Mutation rewiring degron network	0.1667
p.G2189S	SIDM01641	Non-Cancerous	GDSC	PSSSS	DEG_SPOP_SBC_1	2191:2195	Mutation rewiring degron network	0.2778
p.G2189S	SIDM00208	Glioblastoma	GDSC	PSSSS	DEG_SPOP_SBC_1	2191:2195	Mutation rewiring degron network	0.2778
p.H551R	SIDM00379	Glioma	GDSC	PKSSS	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.25
p.H551R	SK-MG-1	central nervous system	COSMIC	PKSSS	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.25
p.V2190A	SNU-1040	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	2191:2195	Mutation rewiring degron network	0.3056
p.L2002M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PLTTS	DEG_SPOP_SBC_1	1997:2001	Mutation rewiring degron network	0.3056
p.R2199I	MDA-MB-361	breast	COSMIC	PSSSS	DEG_SPOP_SBC_1	2191:2195	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons