DegronMD - Q96S66(CLCC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R381W	TCGA-34-7107	LUSC	TCGA	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.1944
p.R388I	TCGA-B5-A1MR	UCEC	TCGA	DYR	CBL_MET	386:388	Mutation altering degron motif	0.8102
p.D397N	TCGA-B5-A3FA	UCEC	TCGA	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.0833
p.D397N	TCGA-D5-6927	COAD	TCGA	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.0833
p.D397N	TCGA-EO-A22R	UCEC	TCGA	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.0833
p.D397N	SIDM01611	Endometrial Carcinoma	GDSC	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.0833
p.D397N	ACH-000996	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.0833
p.E383D	TCGA-BR-8368	STAD	TCGA	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.25
p.A396T	TCGA-MP-A4T4	LUAD	TCGA	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.1111
p.D390H	SIDM00590	Oral Cavity Carcinoma	GDSC	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.2778
p.D390H	ACH-000472	Head and Neck Cancer	CCLE	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.2778
p.D390H	HSC-2	upper aerodigestive tract	COSMIC	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.2778
p.R377W	SIDM00650	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.0833
p.R377W	SIDM01681	Non-Cancerous	GDSC	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.0833
p.F398L	ACH-000982	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.0556
p.A390T	ME-1	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.2778
p.T385I	NCI-H1155	lung	COSMIC	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.3056
p.A394V	H2818	pleura	COSMIC	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.1667
p.A391E	H-EMC-SS	bone	COSMIC	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.25
p.A394S	KALS-1	central nervous system	COSMIC	DYR	CBL_MET	386:388	Mutation rewiring degron network	0.1667

Kaplan plot for CLCC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLCC1

UniProt ID: Q96S66

Entrez ID: 23155

Protein name: Chloride channel CLIC-like protein 1 (Mid-1-related chloride channel protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLCC1 in