DegronMD - Q96S82(UBL7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S255F	TCGA-21-1079	LUSC	TCGA	PSSST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1389
p.S255F	DO26846	LUSC	ICGC	PSSST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1389
p.S255F	DO220890	MELA	ICGC	PSSST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1389
p.P291S	TCGA-5L-AAT1	BRCA	TCGA	PESSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.P291S	DO219594	BRCA	ICGC	PESSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.P282L	TCGA-BR-6452	STAD	TCGA	PESSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7582
p.P282L	TCGA-BR-6566	STAD	TCGA	PESSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7582
p.P282L	DO38404	STAD	ICGC	PESSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7582
p.P282L	DO38217	STAD	ICGC	PESSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7582
p.G257W	TCGA-CV-6953	HNSC	TCGA	PSSST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.0833
p.G257W	DO14278	HNSC	ICGC	PSSST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.0833
p.A277V	TCGA-D1-A17F	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.A277V	DO43362	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.P244L	TCGA-FS-A1ZZ	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7582
p.P244L	DO37412	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7582
p.R252C	TCGA-G4-6628	COAD	TCGA	PSSST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2222
p.R252C	DO10132	COAD	ICGC	PSSST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2222
p.H287Y	TCGA-QB-A6FS	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.H287Y	DO48654	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.A275T	DO232224	PBCA	ICGC	PESSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.P244S	DO229465	SKCA	ICGC	PSSST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.6752
p.A275V	SIDM01175	Other Sarcomas	GDSC	PESSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.A275V	ACH-002309	Sarcoma	CCLE	PESSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.A275V	SW684	soft tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.S251F	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.25
p.S251F	ACH-002220	Lymphoma	CCLE	PSSST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.25
p.S251F	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.25
p.S246N	SIDM00220	Ovarian Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7069
p.S246N	ACH-000962	Ovarian Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7069
p.S246N	ACH-001145	Ovarian Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7069
p.S246N	OC-314	ovary	COSMIC	PSSST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBL7

UniProt ID: Q96S82

Entrez ID: 84993

Protein name: Ubiquitin-like protein 7 (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP) (Ubiquitin-like protein SB132)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBL7 in