DegronMD - Q96ST3(SIN3A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D177N	TCGA-EI-6917	READ	TCGA	PPGY	ITCH	187:190	Mutation rewiring degron network	0.0556
p.D177N	TCGA-EO-A22U	UCEC	TCGA	PPGY	ITCH	187:190	Mutation rewiring degron network	0.0556
p.D177N	DO36881	READ	ICGC	PPGY	ITCH	187:190	Mutation rewiring degron network	0.0556
p.D177N	DO43755	UCEC	ICGC	PPGY	ITCH	187:190	Mutation rewiring degron network	0.0556
p.H29Y	TCGA-EK-A2IP	CESC	TCGA	PPVY	ITCH	38:41	Mutation rewiring degron network	0.0833
p.H29Y	DO228488	BRCA	ICGC	PPVY	ITCH	38:41	Mutation rewiring degron network	0.0833
p.H29Y	DO48978	CESC	ICGC	PPVY	ITCH	38:41	Mutation rewiring degron network	0.0833
p.F182L	TCGA-IQ-A61E	HNSC	TCGA	PPGY	ITCH	187:190	Mutation rewiring degron network	0.1944
p.F182L	DO44429	HNSC	ICGC	PPGY	ITCH	187:190	Mutation rewiring degron network	0.1944
p.P187S	DO222864	COCA	ICGC	PPGY	ITCH	187:190	Mutation altering degron motif	0.6752
p.I192T	DO222586	ESCA	ICGC	PPGY	ITCH	187:190	Mutation rewiring degron network	0.2778
p.G189A	DO233146	GACA	ICGC	PPGY	ITCH	187:190	Mutation altering degron motif	0.6429
p.R32W	DO228943	LICA	ICGC	PPVY	ITCH	38:41	Mutation rewiring degron network	0.1667
p.H31R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPVY	ITCH	38:41	Mutation rewiring degron network	0.1389
p.H31R	ACH-002272	Lymphoma	CCLE	PPVY	ITCH	38:41	Mutation rewiring degron network	0.1389
p.H31R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	38:41	Mutation rewiring degron network	0.1389
p.V33L	SIDM00544	Neuroblastoma	GDSC	PPVY	ITCH	38:41	Mutation rewiring degron network	0.1944
p.V33L	ACH-001716	Neuroblastoma	CCLE	PPVY	ITCH	38:41	Mutation rewiring degron network	0.1944
p.V33L	GOTO	autonomic ganglia	COSMIC	PPVY	ITCH	38:41	Mutation rewiring degron network	0.1944
p.P187H	SIDM00699	Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	187:190	Mutation altering degron motif	0.7694
p.P187H	ACH-001138	Lung Cancer	CCLE	PPGY	ITCH	187:190	Mutation altering degron motif	0.7694
p.P187H	NCI-H2141	lung	COSMIC	PPGY	ITCH	187:190	Mutation altering degron motif	0.7694
p.M48V	SIDM01502	Endometrial Carcinoma	GDSC	PPVY	ITCH	38:41	Mutation rewiring degron network	0.1389
p.M48V	ACH-000435	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	38:41	Mutation rewiring degron network	0.1389
p.T184I	ACH-001322	Sarcoma	CCLE	PPGY	ITCH	187:190	Mutation rewiring degron network	0.25

Kaplan plot for SIN3A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIN3A

UniProt ID: Q96ST3

Entrez ID: 25942

Protein name: Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIN3A in