DegronMD - Q96SZ6(CDK5RAP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R81H	DO230312	COCA	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.1944
p.R81H	DO233652	GACA	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.1944
p.R81H	DO41133	UCEC	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.1944
p.R81H	DO42665	UCEC	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.1944
p.M94I	DO48225	ESCA	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.1944
p.M94I	DO32576	OV	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.1944
p.L86M	DO231201	LUSC	ICGC	PPPY	ITCH	86:89	Mutation altering degron motif	0.711
p.S80F	DO222743	MELA	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.R79Q	DO46657	PAAD	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.1389
p.S82F	DO51276	SKCM	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2222
p.C93G	DO51254	SKCM	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2222
p.R83Q	DO51761	STAD	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.25
p.K99N	DO42280	UCEC	ICGC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.0556
p.R87M	DO43186	UCEC	ICGC	PPPY	ITCH	86:89	Mutation altering degron motif	0.8632
p.M91T	SIDM01265	Plasma Cell Myeloma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM00393	Gastric Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM00846	Cervical Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM00690	Head and Neck Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM00529	Breast Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM01039	Other Solid Cancers	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM00032	Bladder Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM00793	Burkitt's Lymphoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM00954	Breast Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM00863	Burkitt's Lymphoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM01318	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.M91T	SIDM01387	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.P87L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	86:89	Mutation altering degron motif	0.7582
p.P87L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	86:89	Mutation altering degron motif	0.7582
p.P87L	ACH-000995	Leukemia	CCLE	PPPY	ITCH	86:89	Mutation altering degron motif	0.7582
p.P87L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	86:89	Mutation altering degron motif	0.7582

Kaplan plot for CDK5RAP1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK5RAP1

UniProt ID: Q96SZ6

Entrez ID: 51654

Protein name: Mitochondrial tRNA methylthiotransferase CDK5RAP1 (EC 2.8.4.3) (CDK5 activator-binding protein C42) (CDK5 regulatory subunit-associated protein 1) (mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase) (mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CDK5RAP1 in