DegronMD - Q99469(STAC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P25S	TCGA-17-Z055	LUAD	TCGA	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.Q24L	TCGA-55-7570	LUAD	TCGA	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.2222
p.Q24L	DO25280	LUAD	ICGC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.2222
p.P25L	TCGA-AA-A022	COAD	TCGA	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.P25L	DO10647	COAD	ICGC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.P25L	DO233888	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.A19V	TCGA-B5-A1MR	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.A19V	DO41758	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.A19V	SIDM02047	Colorectal Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.A19V	SIDM00217	Colorectal Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.A19V	ACH-000999	Colon/Colorectal Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.A19V	SNU-1040	large intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.G21S	TCGA-D3-A5GS	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.G21S	DO47706	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.S30F	TCGA-DA-A3F8	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7982
p.S30F	DO37418	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7982
p.E23G	TCGA-GS-A9TT	DLBC	TCGA	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.E23G	DO219912	DLBC	ICGC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.L41I	DO234230	ESAD	ICGC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.L41Q	DO229208	THCA	ICGC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.E18D	SIDM00333	Endometrial Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0556
p.E18D	ACH-000988	Endometrial/Uterine Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0556
p.E18D	MFE-319	endometrium	COSMIC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0556
p.E23Q	SIDM00414	Bladder Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.P28L	SIDM00140	Melanoma	GDSC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7582
p.P28L	ACH-000968	Skin Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7582
p.P28L	COLO-792	skin	COSMIC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7582
p.K42T	SIDM01588	Endometrial Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	28:32	Mutation substituting flanking lysine	0.1667
p.K42T	ACH-000993	Endometrial/Uterine Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	28:32	Mutation substituting flanking lysine	0.1667

Kaplan plot for STAC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STAC

UniProt ID: Q99469

Entrez ID: 6769

Protein name: SH3 and cysteine-rich domain-containing protein (Src homology 3 and cysteine-rich domain-containing protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STAC in