DegronMD - Q99626(CDX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y37H	TCGA-12-0818	GBM	TCGA	PPQY	ITCH	34:37	Mutation altering degron motif	0.7229
p.Y37H	DO12892	GBM	ICGC	PPQY	ITCH	34:37	Mutation altering degron motif	0.7229
p.N25K	TCGA-MF-A522	LUSC	TCGA	PPQY	ITCH	34:37	Mutation rewiring degron network	0.0833
p.N25K	DO45526	LUSC	ICGC	PPQY	ITCH	34:37	Mutation rewiring degron network	0.0833
p.G41S	DO227802	COCA	ICGC	PPQY	ITCH	34:37	Mutation rewiring degron network	0.2222
p.A46E	DO229041	LICA	ICGC	PPQY	ITCH	34:37	Mutation rewiring degron network	0.0833
p.S33N	SIDM00554	Ovarian Carcinoma	GDSC	PPQY	ITCH	34:37	Mutation rewiring degron network	0.3056
p.S33N	ACH-000524	Ovarian Cancer	CCLE	PPQY	ITCH	34:37	Mutation rewiring degron network	0.3056
p.S33N	KURAMOCHI	ovary	COSMIC	PPQY	ITCH	34:37	Mutation rewiring degron network	0.3056
p.Y43H	SIDM01424	B-Lymphoblastic Leukemia	GDSC	PPQY	ITCH	34:37	Mutation rewiring degron network	0.1667
p.Y43H	ACH-000782	Leukemia	CCLE	PPQY	ITCH	34:37	Mutation rewiring degron network	0.1667
p.Y43H	ACH-001735	Leukemia	CCLE	PPQY	ITCH	34:37	Mutation rewiring degron network	0.1667
p.V32I	ACH-000945	Lung Cancer	CCLE	PPQY	ITCH	34:37	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons