DegronMD - Q99717(SMAD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T201I	TCGA-AX-A3G9	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7078
p.T201I	DO41241	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7078
p.D231V	TCGA-CK-4951	COAD	TCGA	PPAY	ITCH	223:226	Mutation rewiring degron network	0.1944
p.D231V	DO10582	COAD	ICGC	PPAY	ITCH	223:226	Mutation rewiring degron network	0.1944
p.T221S	TCGA-W5-AA2T	CHOL	TCGA	PPAY	ITCH	223:226	Mutation rewiring degron network	0.2778
p.A219V	DO225215	BRCA	ICGC	PPAY	ITCH	223:226	Mutation rewiring degron network	0.2222
p.A219V	DO227836	BRCA	ICGC	PPAY	ITCH	223:226	Mutation rewiring degron network	0.2222
p.M227V	DO231064	LUSC	ICGC	PPAY	ITCH	223:226	Mutation rewiring degron network	0.3056
p.Q216L	DO46424	OV	ICGC	PPAY	ITCH	223:226	Mutation rewiring degron network	0.1389
p.S205F	SIDM00180	Kidney Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2222
p.S205F	ACH-002155	Kidney Cancer	CCLE	PASST	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2222
p.S205F	LB996-RCC	kidney	COSMIC	PASST	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2222
p.Q216E	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	223:226	Mutation rewiring degron network	0.1389
p.Q216E	ACH-000787	Lung Cancer	CCLE	PPAY	ITCH	223:226	Mutation rewiring degron network	0.1389
p.Q216E	LXF-289	lung	COSMIC	PPAY	ITCH	223:226	Mutation rewiring degron network	0.1389
p.S213R	SIDM00118	Colorectal Carcinoma	GDSC	PPAY	ITCH	223:226	Mutation rewiring degron network	0.0556
p.S213R	ACH-001081	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	223:226	Mutation rewiring degron network	0.0556
p.S213R	HCC2998	large intestine	COSMIC	PPAY	ITCH	223:226	Mutation rewiring degron network	0.0556

Kaplan plot for SMAD5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMAD5

UniProt ID: Q99717

Entrez ID: 4090

Protein name: Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMAD5 in