DegronMD - Q99759(MAP3K3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E190K	TCGA-06-5416	GBM	TCGA	PPGY	ITCH	178:181	Mutation rewiring degron network	0.0833
p.Q177R	TCGA-43-8118	LUSC	TCGA	PPGY	ITCH	178:181	Mutation rewiring degron network	0.3056
p.A179V	TCGA-BH-A0HF	BRCA	TCGA	PPGY	ITCH	178:181	Mutation altering degron motif	0.6936
p.G180W	TCGA-DF-A2KU	UCEC	TCGA	PPGY	ITCH	178:181	Mutation altering degron motif	0.6714
p.G180W	DO223286	UCEC	ICGC	PPGY	ITCH	178:181	Mutation altering degron motif	0.6714
p.V171L	TCGA-J4-A83N	PRAD	TCGA	PPGY	ITCH	178:181	Mutation rewiring degron network	0.1389
p.V171L	DO49843	PRAD	ICGC	PPGY	ITCH	178:181	Mutation rewiring degron network	0.1389
p.P178L	DO8842	COAD	ICGC	PPGY	ITCH	178:181	Mutation altering degron motif	0.7582
p.R191W	DO228114	EOPC	ICGC	PPGY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.R191W	DO233884	GACA	ICGC	PPGY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.R191W	ACH-000686	Liver Cancer	CCLE	PPGY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.R185W	DO233732	GACA	ICGC	PPGY	ITCH	178:181	Mutation rewiring degron network	0.2222
p.R172L	DO228948	LICA	ICGC	PPGY	ITCH	178:181	Mutation rewiring degron network	0.1667
p.A175S	DO229025	LICA	ICGC	PPGY	ITCH	178:181	Mutation blocking phosphorylation signal	0.6944
p.NP171NS	DO222632	MELA	ICGC	PPGY	ITCH	178:181	Mutation rewiring degron network	0
p.P188L	DO222837	MELA	ICGC	PPGY	ITCH	178:181	Mutation rewiring degron network	0.1389
p.S168T	DO27931	ORCA	ICGC	PPGY	ITCH	178:181	Mutation blocking phosphorylation signal	0.5
p.P172S	DO37571	SKCM	ICGC	PPGY	ITCH	178:181	Mutation rewiring degron network	0.1667
p.A190T	DO42560	UCEC	ICGC	PPGY	ITCH	178:181	Mutation rewiring degron network	0.0833
p.R191Q	DO41199	UCEC	ICGC	PPGY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.R169G	SIDM01279	Colorectal Carcinoma	GDSC	PPGY	ITCH	178:181	Mutation blocking phosphorylation signal	0.5278
p.S175N	ACH-001345	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	178:181	Mutation blocking phosphorylation signal	0.6944
p.S175N	GP5d	large intestine	COSMIC	PPGY	ITCH	178:181	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for MAP3K3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K3

UniProt ID: Q99759

Entrez ID: 4215

Protein name: Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K3 in