DegronMD - Q99814(EPAS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P485H	TCGA-06-5416	GBM	TCGA	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0833
p.P485H	DO10880	GBM	ICGC	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0833
p.A404T	TCGA-2G-AALW	TGCT	TCGA	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation altering degron motif	0.7139
p.C546F	TCGA-53-7624	LUAD	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.2222
p.C546F	DO25058	LUAD	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.2222
p.N483S	TCGA-58-8391	LUSC	TCGA	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1389
p.N483S	TCGA-61-2002	OV	TCGA	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1389
p.N483S	DO45440	LUSC	ICGC	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1389
p.N483S	DO27994	OV	ICGC	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1389
p.T519M	TCGA-AN-A0AK	BRCA	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.0556
p.T519M	DO1608	BRCA	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.0556
p.S474T	TCGA-AP-A1DM	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.6005
p.S474T	TCGA-BR-A4QL	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.6005
p.S474T	DO229004	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.6005
p.S474T	DO38723	STAD	ICGC	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.6005
p.S474T	DO43106	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.6005
p.R550W	TCGA-AX-A3FT	UCEC	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.1111
p.R550W	TCGA-BR-8361	STAD	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.1111
p.R550W	DO48032	STAD	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.1111
p.R550W	DO40801	UCEC	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.1111
p.R550W	SIDM01619	Endometrial Carcinoma	GDSC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.1111
p.R550W	ACH-000984	Endometrial/Uterine Cancer	CCLE	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.1111
p.P407T	TCGA-BA-5555	HNSC	TCGA	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation altering degron motif	0.5919
p.P407T	DO14220	HNSC	ICGC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation altering degron motif	0.5919
p.E538K	TCGA-DA-A1HY	SKCM	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.591
p.E538K	DO37409	SKCM	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.591
p.E538K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.591
p.E538K	ACH-000916	Lung Cancer	CCLE	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.591
p.E538K	NCI-H1573	lung	COSMIC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.591
p.V459M	TCGA-DI-A2QU	UCEC	TCGA	PGSTT	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.V459M	DO42616	UCEC	ICGC	PGSTT	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.P531L	TCGA-QR-A7IN	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.7582
p.P531L	TCGA-QT-A7U0	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.7582
p.P531S	TCGA-QT-A5XL	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.6752
p.Y532C	TCGA-RW-A68D	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.5976
p.Y532C	TCGA-SR-A6MV	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.5976
p.P531A	TCGA-S7-A7X0	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.7503
p.S594I	TCGA-VQ-A91D	STAD	TCGA	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation rewiring degron network	0.0833
p.S594I	DO51783	STAD	ICGC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation rewiring degron network	0.0833
p.P579T	TCGA-VQ-AA69	STAD	TCGA	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation altering degron motif	0.5919
p.P579T	TCGA-VQ-AA69	STAD	TCGA	QPLAPVAPH	DEG_SIAH_1	572:580	Mutation altering degron motif	0.7031
p.P579T	DO222385	STAD	ICGC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation altering degron motif	0.5919
p.P579T	DO222385	STAD	ICGC	QPLAPVAPH	DEG_SIAH_1	572:580	Mutation altering degron motif	0.7031
p.A530V	TCGA-WB-A814	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.6936
p.A530V	TCGA-WB-A821	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.6936
p.E398K	DO225366	BRCA	ICGC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation rewiring degron network	0.1944
p.T528I	DO222427	BTCA	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation blocking phosphorylation signal	0.75
p.E593K	DO234350	ESAD	ICGC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation rewiring degron network	0.1111
p.E396D	DO229041	LICA	ICGC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation rewiring degron network	0.1389
p.L542R	DO23256	LINC	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation altering degron motif	0.8428
p.A410T	DO231691	LINC	ICGC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation altering degron motif	0.6028
p.N522S	DO52365	LUSC	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.1389
p.N522S	SIDM01079	Melanoma	GDSC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.1389
p.N522S	ACH-000441	Skin Cancer	CCLE	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.1389
p.N522S	SH-4	skin	COSMIC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.1389
p.G408E	DO220896	MELA	ICGC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation altering degron motif	0.6087
p.D520N	DO222753	MELA	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	529:542	Mutation rewiring degron network	0.0833
p.P455T	DO229275	THCA	ICGC	PGSTT	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0556
p.L403R	SIDM00417	Plasma Cell Myeloma	GDSC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation altering degron motif	0.8428
p.L403R	ACH-000626	Myeloma	CCLE	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation altering degron motif	0.8428
p.L403R	U-266	haematopoietic and lymphoid tissue	COSMIC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation altering degron motif	0.8428
p.L584I	SIDM00282	Colorectal Carcinoma	GDSC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation altering degron motif	0.6063
p.L584I	ACH-000998	Colon/Colorectal Cancer	CCLE	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation altering degron motif	0.6063
p.L584I	CW-2	large intestine	COSMIC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation altering degron motif	0.6063
p.F564L	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation rewiring degron network	0.0556
p.F564L	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	QPLAPVAPH	DEG_SIAH_1	572:580	Mutation rewiring degron network	0.1111
p.F564L	ACH-000309	Lung Cancer	CCLE	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation rewiring degron network	0.0556
p.F564L	ACH-000309	Lung Cancer	CCLE	QPLAPVAPH	DEG_SIAH_1	572:580	Mutation rewiring degron network	0.1111
p.F564L	SK-LU-1	lung	COSMIC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	574:585	Mutation rewiring degron network	0.0556
p.F564L	SK-LU-1	lung	COSMIC	QPLAPVAPH	DEG_SIAH_1	572:580	Mutation rewiring degron network	0.1111
p.P465R	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7512
p.P465R	ACH-000672	Lung Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7512
p.P465R	IA-LM	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7512
p.F421L	ACH-001536	Bile Duct Cancer	CCLE	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	403:416	Mutation rewiring degron network	0.1944

Kaplan plot for EPAS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPAS1

UniProt ID: Q99814

Entrez ID: 2034

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPAS1 in