DegronMD - Q99835(SMO)

GO - Biological processes (BP): anterior/posterior pattern specification [GO:0009952]; astrocyte activation [GO:0048143]; atrial septum morphogenesis [GO:0060413]; cell fate specification [GO:0001708]; cellular response to cholesterol [GO:0071397]; central nervous system development [GO:0007417]; central nervous system neuron differentiation [GO:0021953]; cerebellar cortex morphogenesis [GO:0021696]; cerebral cortex development [GO:0021987]; commissural neuron axon guidance [GO:0071679]; contact inhibition [GO:0060242]; dentate gyrus development [GO:0021542]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dorsal/ventral neural tube patterning [GO:0021904]; epithelial-mesenchymal cell signaling [GO:0060684]; forebrain morphogenesis [GO:0048853]; hair follicle morphogenesis [GO:0031069]; heart looping [GO:0001947]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mammary gland epithelial cell differentiation [GO:0060644]; mesenchymal to epithelial transition involved in metanephric renal vesicle formation [GO:0072285]; midgut development [GO:0007494]; multicellular organism growth [GO:0035264]; myoblast migration [GO:0051451]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA binding [GO:0043392]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of gene expression [GO:0010629]; negative regulation of hair follicle development [GO:0051799]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pancreas morphogenesis [GO:0061113]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of organ growth [GO:0046622]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; regulation of heart morphogenesis [GO:2000826]; regulation of stem cell population maintenance [GO:2000036]; skeletal muscle fiber development [GO:0048741]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938]; smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021910]; smooth muscle tissue development [GO:0048745]; somite development [GO:0061053]; thalamus development [GO:0021794]; type B pancreatic cell development [GO:0003323]; vasculogenesis [GO:0001570]; ventral midline determination [GO:0007371] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L780R	TCGA-06-5416	GBM	TCGA	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.0556
p.L780R	DO10880	GBM	ICGC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.0556
p.V642L	TCGA-67-6217	LUAD	TCGA	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation altering degron motif	0.5654
p.V642L	DO25877	LUAD	ICGC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation altering degron motif	0.5654
p.P641R	TCGA-69-7979	LUAD	TCGA	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation altering degron motif	0.7512
p.P641R	DO23874	LUAD	ICGC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation altering degron motif	0.7512
p.P634L	TCGA-78-7220	LUAD	TCGA	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P634L	DO24409	LUAD	ICGC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.A754T	TCGA-AP-A059	UCEC	TCGA	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1111
p.A754T	DO41361	UCEC	ICGC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1111
p.Q635H	TCGA-AP-A0LM	UCEC	TCGA	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.2778
p.Q635H	DO43306	UCEC	ICGC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.2778
p.P768S	TCGA-BH-A0B8	BRCA	TCGA	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation altering degron motif	0.5641
p.P768S	DO5486	BRCA	ICGC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation altering degron motif	0.5641
p.P645T	TCGA-CN-A63Y	HNSC	TCGA	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.3056
p.P645T	DO44422	HNSC	ICGC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.3056
p.S771F	TCGA-ER-A198	SKCM	TCGA	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation blocking phosphorylation signal	0.75
p.S771F	DO47563	SKCM	ICGC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation blocking phosphorylation signal	0.75
p.A757V	TCGA-EY-A215	UCEC	TCGA	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1944
p.A757V	DO42665	UCEC	ICGC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1944
p.D636N	TCGA-FS-A4F5	SKCM	TCGA	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.3056
p.D636N	DO37881	SKCM	ICGC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.3056
p.D636N	ACH-000941	Endometrial/Uterine Cancer	CCLE	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.3056
p.P753L	TCGA-UY-A8OB	BLCA	TCGA	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.0833
p.P753L	DO219037	BLCA	ICGC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.0833
p.V639A	TCGA-VQ-A8PB	STAD	TCGA	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation altering degron motif	0.5825
p.V639A	DO51766	STAD	ICGC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation altering degron motif	0.5825
p.W758R	TCGA-ZS-A9CG	LIHC	TCGA	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.2222
p.W758R	DO52336	LIHC	ICGC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.2222
p.Q764H	DO8858	COAD	ICGC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation altering degron motif	0.647
p.R628Q	DO233112	GACA	ICGC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.0833
p.G630E	DO222714	MELA	ICGC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.1389
p.M776I	DO37432	SKCM	ICGC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1667
p.Q635K	DO229234	THCA	ICGC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.2778
p.P647S	SIDM01139	Pancreatic Carcinoma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P647S	SIDM01878	Non-Cancerous	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P647S	SIDM00099	Mesothelioma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P647S	SIDM00343	Glioblastoma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P647S	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P647S	SIDM00053	Pancreatic Carcinoma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P647S	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P647S	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P647S	SIDM01739	Small Cell Lung Carcinoma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P647S	SIDM01475	Ovarian Carcinoma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.P647S	SIDM01491	Colorectal Carcinoma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation rewiring degron network	0.25
p.R772C	SIDM00074	Burkitt's Lymphoma	GDSC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.2778
p.T640A	SIDM00789	Colorectal Carcinoma	GDSC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation altering degron motif	0.7139
p.T640A	ACH-000997	Colon/Colorectal Cancer	CCLE	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation altering degron motif	0.7139
p.T640A	ACH-001061	Colon/Colorectal Cancer	CCLE	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation altering degron motif	0.7139
p.T640A	HCT-15	large intestine	COSMIC	ISVTPVAT	DEG_SCF_FBW7_1	637:644	Mutation altering degron motif	0.7139
p.R763Q	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation altering degron motif	0.7329
p.R763Q	SIDM01146	Gastric Carcinoma	GDSC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation altering degron motif	0.7329
p.R763Q	ACH-000932	Gastric Cancer	CCLE	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation altering degron motif	0.7329
p.R763Q	ACH-000980	Lung Cancer	CCLE	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation altering degron motif	0.7329
p.R763Q	NCI-SNU-1	stomach	COSMIC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation altering degron motif	0.7329
p.R763Q	NCI-H1155	lung	COSMIC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation altering degron motif	0.7329
p.R772H	SIDM00217	Colorectal Carcinoma	GDSC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.2778
p.R772H	ACH-000999	Colon/Colorectal Cancer	CCLE	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.2778
p.R772H	SNU-1040	large intestine	COSMIC	RRQGLGPIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.2778

Kaplan plot for SMO in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMO

UniProt ID: Q99835

Entrez ID: 6608

Protein name: Smoothened homolog (SMO) (Protein Gx)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SMO in