DegronMD - Q99836(MYD88)

GO - Biological processes (BP): 3'-UTR-mediated mRNA stabilization [GO:0070935]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; establishment of endothelial intestinal barrier [GO:0090557]; immunoglobulin mediated immune response [GO:0016064]; induced systemic resistance [GO:0009682]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; JNK cascade [GO:0007254]; leukocyte activation involved in inflammatory response [GO:0002269]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil activation involved in immune response [GO:0002283]; neutrophil-mediated killing of bacterium [GO:0070944]; phagocytosis [GO:0006909]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000338]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of inflammatory response [GO:0050727]; regulation of neutrophil migration [GO:1902622]; response to interleukin-1 [GO:0070555]; response to molecule of fungal origin [GO:0002238]; response to peptidoglycan [GO:0032494]; signal transduction [GO:0007165]; toll-like receptor 8 signaling pathway [GO:0034158]; Toll signaling pathway [GO:0008063]; type I interferon signaling pathway [GO:0060337] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A24T	TCGA-BT-A3PK	BLCA	TCGA	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1389
p.A24T	DO44051	BLCA	ICGC	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1389
p.G22R	TCGA-MA-AA3X	CESC	TCGA	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.G22R	DO219720	CESC	ICGC	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.R5S	TCGA-UF-A71A	HNSC	TCGA	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.R5S	DO52106	HNSC	ICGC	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.R5C	DO50383	ESAD	ICGC	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.G22V	DO229019	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.A8S	DO229035	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.S23Y	DO231736	LINC	ICGC	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1667
p.P9S	SIDM00234	Other Solid Cancers	GDSC	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2222
p.P9S	TC-YIK	cervix	COSMIC	PVSST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYD88

UniProt ID: Q99836

Entrez ID: 4615

Protein name: Myeloid differentiation primary response protein MyD88

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYD88 in