FUNCTION: Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in re...
FUNCTION: Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression. {ECO:0000250|UniProtKB:O35449}.
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GO - Biological processes (BP):
learning or memory [GO:0007611]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; protein localization to cell surface [GO:0034394]; protein phosphorylation [GO:0006468]; regulation of AMPA receptor activity [GO:2000311]; synapse organization [GO:0050808]...
learning or memory [GO:0007611]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; protein localization to cell surface [GO:0034394]; protein phosphorylation [GO:0006468]; regulation of AMPA receptor activity [GO:2000311]; synapse organization [GO:0050808]
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GO - Molecular function (MF):
identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]...
identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]; membrane [GO:0016020]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672]...
integral component of membrane [GO:0016021]; membrane [GO:0016020]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672]
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