DegronMD - Q99954(SMR3A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P81L	TCGA-06-5416	GBM	TCGA	PPPY	ITCH	81:84	Mutation altering degron motif	0.7582
p.P81L	DO10880	GBM	ICGC	PPPY	ITCH	81:84	Mutation altering degron motif	0.7582
p.S91L	TCGA-06-5416	GBM	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1389
p.S91L	TCGA-06-5416	GBM	TCGA	PPPY	ITCH	95:98	Mutation rewiring degron network	0.2222
p.S91L	DO10880	GBM	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1389
p.S91L	DO10880	GBM	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.2222
p.P73S	TCGA-3N-A9WD	SKCM	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1111
p.P73S	DO51235	SKCM	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1111
p.P100A	TCGA-55-7994	LUAD	TCGA	PPPY	ITCH	95:98	Mutation rewiring degron network	0.2778
p.P100A	DO45311	LUAD	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.2778
p.H54D	TCGA-91-7771	LUAD	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.3056
p.H54D	DO25807	LUAD	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.3056
p.G87E	TCGA-AA-3666	COAD	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.25
p.G87E	TCGA-AA-3666	COAD	TCGA	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1111
p.G87E	DO9042	COAD	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.25
p.G87E	DO9042	COAD	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1111
p.R88I	TCGA-AG-3893	READ	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2222
p.R88I	TCGA-AG-3893	READ	TCGA	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1389
p.R88I	TCGA-CA-6718	COAD	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2222
p.R88I	TCGA-CA-6718	COAD	TCGA	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1389
p.R88I	DO7801	COAD	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2222
p.R88I	DO7801	COAD	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1389
p.R88I	DO222884	COCA	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2222
p.R88I	DO222884	COCA	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1389
p.R88I	DO36640	READ	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2222
p.R88I	DO36640	READ	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1389
p.S93Y	TCGA-AP-A056	UCEC	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.S93Y	TCGA-AP-A056	UCEC	TCGA	PPPY	ITCH	95:98	Mutation rewiring degron network	0.2778
p.S93Y	DO43971	UCEC	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.S93Y	DO43971	UCEC	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.2778
p.G46E	TCGA-AX-A05Z	UCEC	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.0833
p.G46E	TCGA-GN-A266	SKCM	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.0833
p.G46E	DO37432	SKCM	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.0833
p.G46E	DO40884	UCEC	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.0833
p.R62T	TCGA-BT-A20R	BLCA	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.2222
p.R62T	DO622	BLCA	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.2222
p.G74E	TCGA-CC-A7IE	LIHC	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1389
p.G74E	DO52175	LIHC	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1389
p.G99D	TCGA-CK-6746	COAD	TCGA	PPPY	ITCH	95:98	Mutation rewiring degron network	0.3056
p.G99D	DO7938	COAD	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.3056
p.Q90L	TCGA-CN-A499	HNSC	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1667
p.Q90L	TCGA-CN-A499	HNSC	TCGA	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1944
p.Q90L	DO52040	HNSC	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1667
p.Q90L	DO52040	HNSC	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1944
p.P60T	TCGA-CR-7398	HNSC	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.2778
p.P60T	DO14782	HNSC	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.2778
p.P56S	TCGA-D3-A8GM	SKCM	TCGA	PPPY	ITCH	55:58	Mutation altering degron motif	0.6752
p.P56S	DO50288	SKCM	ICGC	PPPY	ITCH	55:58	Mutation altering degron motif	0.6752
p.P56L	TCGA-D3-A8GM	SKCM	TCGA	PPPY	ITCH	55:58	Mutation altering degron motif	0.7582
p.P56L	DO50288	SKCM	ICGC	PPPY	ITCH	55:58	Mutation altering degron motif	0.7582
p.P65Q	TCGA-D7-A4YV	STAD	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.1389
p.P65Q	DO47777	STAD	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.1389
p.L67I	TCGA-DD-A1EB	LIHC	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.0833
p.L67I	DO22836	LIHC	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.0833
p.P97S	TCGA-EB-A3Y7	SKCM	TCGA	PPPY	ITCH	95:98	Mutation altering degron motif	0.5641
p.P97S	TCGA-ER-A42L	SKCM	TCGA	PPPY	ITCH	95:98	Mutation altering degron motif	0.5641
p.P97S	DO37499	SKCM	ICGC	PPPY	ITCH	95:98	Mutation altering degron motif	0.5641
p.P97S	DO223910	SKCM	ICGC	PPPY	ITCH	95:98	Mutation altering degron motif	0.5641
p.P95S	TCGA-EE-A29E	SKCM	TCGA	PPPY	ITCH	95:98	Mutation altering degron motif	0.6752
p.P95S	TCGA-EE-A2MS	SKCM	TCGA	PPPY	ITCH	95:98	Mutation altering degron motif	0.6752
p.P95S	DO37567	SKCM	ICGC	PPPY	ITCH	95:98	Mutation altering degron motif	0.6752
p.P95S	DO37831	SKCM	ICGC	PPPY	ITCH	95:98	Mutation altering degron motif	0.6752
p.R88K	TCGA-EE-A2MJ	SKCM	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2222
p.R88K	TCGA-EE-A2MJ	SKCM	TCGA	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1389
p.R88K	DO38099	SKCM	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2222
p.R88K	DO38099	SKCM	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1389
p.G46R	TCGA-FS-A1ZZ	SKCM	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.0833
p.G46R	DO37412	SKCM	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.0833
p.Q90E	TCGA-FU-A2QG	CESC	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1667
p.Q90E	TCGA-FU-A2QG	CESC	TCGA	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1944
p.Q90E	DO6253	CESC	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1667
p.Q90E	DO6253	CESC	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1944
p.R75K	TCGA-G2-A2EO	BLCA	TCGA	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1667
p.R75K	DO48457	BLCA	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1667
p.R75K	DO456	BLCA	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1667
p.P51Q	TCGA-L9-A444	LUAD	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.2222
p.P51Q	DO26015	LUAD	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.2222
p.P52T	TCGA-L9-A444	LUAD	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.25
p.P52T	DO26015	LUAD	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.25
p.P81T	TCGA-NJ-A4YF	LUAD	TCGA	PPPY	ITCH	81:84	Mutation altering degron motif	0.7031
p.P81T	DO218940	LUAD	ICGC	PPPY	ITCH	81:84	Mutation altering degron motif	0.7031
p.P64S	TCGA-WE-AAA0	SKCM	TCGA	PPPY	ITCH	55:58	Mutation rewiring degron network	0.1667
p.P64S	DO51294	SKCM	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.1667
p.P96S	DO233161	GACA	ICGC	PPPY	ITCH	95:98	Mutation altering degron motif	0.6752
p.G72V	DO228971	LICA	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.G99V	DO229029	LICA	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.3056
p.I89F	DO23256	LINC	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1944
p.I89F	DO23256	LINC	ICGC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1667
p.G48E	DO220881	MELA	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.1389
p.S79F	DO220891	MELA	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2778
p.R62K	DO220890	MELA	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.2222
p.F49Y	DO220906	MELA	ICGC	PPPY	ITCH	55:58	Mutation rewiring degron network	0.1667
p.P80S	DO222843	MELA	ICGC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.3056
p.G72S	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.G72S	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.G72S	SIDM00394	Cervical Carcinoma	GDSC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.G72S	LC-2-ad	lung	COSMIC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.G72S	TE-6	oesophagus	COSMIC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.G72S	SISO	cervix	COSMIC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0833
p.G74W	SIDM00781	Colorectal Carcinoma	GDSC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1389
p.G74W	ACH-001199	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1389
p.G74W	SNU-C2B	large intestine	COSMIC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.1389
p.Y71C	SIDM00238	Ovarian Carcinoma	GDSC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0556
p.Y71C	ACH-000947	Ovarian Cancer	CCLE	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0556
p.Y71C	OVK-18	ovary	COSMIC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.0556
p.P103Q	SIDM01039	Other Solid Cancers	GDSC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1944
p.P103Q	ACH-001529	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1944
p.P103Q	JAR	placenta	COSMIC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1944
p.P106R	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1111
p.P106R	ACH-000945	Lung Cancer	CCLE	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1111
p.P106R	NCI-H650	lung	COSMIC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1111
p.P96H	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	95:98	Mutation altering degron motif	0.7694
p.P96H	ACH-000448	Lung Cancer	CCLE	PPPY	ITCH	95:98	Mutation altering degron motif	0.7694
p.P96H	NCI-H1666	lung	COSMIC	PPPY	ITCH	95:98	Mutation altering degron motif	0.7694
p.P86L	SIDM00861	Ovarian Carcinoma	GDSC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2778
p.P86L	SIDM00861	Ovarian Carcinoma	GDSC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.0833
p.P86L	ACH-000906	Ovarian Cancer	CCLE	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2778
p.P86L	ACH-000906	Ovarian Cancer	CCLE	PPPY	ITCH	95:98	Mutation rewiring degron network	0.0833
p.P86L	ES-2	ovary	COSMIC	PPPY	ITCH	81:84	Mutation rewiring degron network	0.2778
p.P86L	ES-2	ovary	COSMIC	PPPY	ITCH	95:98	Mutation rewiring degron network	0.0833
p.G87R	ACH-000829	Myeloma	CCLE	PPPY	ITCH	81:84	Mutation rewiring degron network	0.25
p.G87R	ACH-000829	Myeloma	CCLE	PPPY	ITCH	95:98	Mutation rewiring degron network	0.1111
p.G85C	ACH-001608	Brain Cancer	CCLE	PPPY	ITCH	81:84	Mutation rewiring degron network	0.3056
p.G85C	ACH-001608	Brain Cancer	CCLE	PPPY	ITCH	95:98	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMR3A

UniProt ID: Q99954

Entrez ID: 26952

Protein name: Submaxillary gland androgen-regulated protein 3A (Proline-rich protein 5) (Proline-rich protein PBI)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMR3A in