DegronMD - Q99958(FOXC2)

GO - Biological processes (BP): anatomical structure morphogenesis [GO:0009653]; artery morphogenesis [GO:0048844]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye development [GO:0043010]; cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; embryonic heart tube development [GO:0035050]; embryonic viscerocranium morphogenesis [GO:0048703]; glomerular endothelium development [GO:0072011]; glomerular mesangial cell development [GO:0072144]; glomerular visceral epithelial cell differentiation [GO:0072112]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; lymphangiogenesis [GO:0001946]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902257]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; Notch signaling pathway [GO:0007219]; ossification [GO:0001503]; paraxial mesodermal cell fate commitment [GO:0048343]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular wound healing [GO:0035470]; regulation of organ growth [GO:0046620]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hormone [GO:0009725]; somitogenesis [GO:0001756]; ureteric bud development [GO:0001657]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P493T	TCGA-17-Z062	LUAD	TCGA	PPLY	ITCH	485:488	Mutation rewiring degron network	0.1944
p.Y496H	TCGA-33-4566	LUSC	TCGA	PPLY	ITCH	485:488	Mutation blocking phosphorylation signal	0.5556
p.Y496H	DO26790	LUSC	ICGC	PPLY	ITCH	485:488	Mutation blocking phosphorylation signal	0.5556
p.R489C	TCGA-AX-A05Z	UCEC	TCGA	PPLY	ITCH	485:488	Mutation rewiring degron network	0.3056
p.R489C	TCGA-FR-A726	SKCM	TCGA	PPLY	ITCH	485:488	Mutation rewiring degron network	0.3056
p.R489C	DO48665	SKCM	ICGC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.3056
p.R489C	DO40884	UCEC	ICGC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.3056
p.P485Q	TCGA-CR-7364	HNSC	TCGA	PPLY	ITCH	485:488	Mutation altering degron motif	0.7035
p.P485Q	DO15679	HNSC	ICGC	PPLY	ITCH	485:488	Mutation altering degron motif	0.7035
p.P485Q	DO27939	ORCA	ICGC	PPLY	ITCH	485:488	Mutation altering degron motif	0.7035
p.P493S	TCGA-DA-A1HV	SKCM	TCGA	PPLY	ITCH	485:488	Mutation rewiring degron network	0.1944
p.P493S	DO37659	SKCM	ICGC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.1944
p.R489L	TCGA-DD-AAEE	LIHC	TCGA	PPLY	ITCH	485:488	Mutation rewiring degron network	0.3056
p.R489L	DO52270	LIHC	ICGC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.3056
p.R489H	DO233737	GACA	ICGC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.3056
p.S495F	DO50880	LICA	ICGC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.1389
p.C498S	DO231837	LINC	ICGC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.0556
p.S495Y	SIDM02037	Pancreatic Carcinoma	GDSC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.1389
p.C498R	SIDM00705	Non-Cancerous	GDSC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.0556
p.C498R	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.0556
p.C498R	SIDM00696	Non-Cancerous	GDSC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.0556
p.C498R	SIDM00772	Breast Carcinoma	GDSC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.0556
p.C498R	SIDM01102	Non-Cancerous	GDSC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.0556
p.S483Y	SIDM00919	Ovarian Carcinoma	GDSC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.2778
p.S483Y	ACH-000713	Ovarian Cancer	CCLE	PPLY	ITCH	485:488	Mutation rewiring degron network	0.2778
p.S483Y	Caov-3	ovary	COSMIC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.2778
p.Y481C	SIDM00293	Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.2222
p.Y481C	ACH-002052	Lung Cancer	CCLE	PPLY	ITCH	485:488	Mutation rewiring degron network	0.2222
p.Y481C	LU-139	lung	COSMIC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.2222
p.Y488C	SIDM00844	Burkitt's Lymphoma	GDSC	PPLY	ITCH	485:488	Mutation altering degron motif	0.7087
p.P485L	SIDM01318	Hepatocellular Carcinoma	GDSC	PPLY	ITCH	485:488	Mutation altering degron motif	0.7582
p.P485L	ACH-001318	Liver Cancer	CCLE	PPLY	ITCH	485:488	Mutation altering degron motif	0.7582
p.P480S	SIDM01611	Endometrial Carcinoma	GDSC	PPLY	ITCH	485:488	Mutation rewiring degron network	0.1944
p.P480S	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPLY	ITCH	485:488	Mutation rewiring degron network	0.1944
p.H490Y	ACH-000718	Lung Cancer	CCLE	PPLY	ITCH	485:488	Mutation rewiring degron network	0.2778

Kaplan plot for FOXC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXC2

UniProt ID: Q99958

Entrez ID: 2303

Protein name: Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXC2 in