FUNCTION: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transac...
FUNCTION: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:21172805}.
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GO - Biological processes (BP):
apoptotic process [GO:0006915]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; labyrinthine layer development [GO:0060711]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; mesenchymal to epithelial transition [GO:006...
apoptotic process [GO:0006915]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; labyrinthine layer development [GO:0060711]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; mesenchymal to epithelial transition [GO:0060231]; metanephros development [GO:0001656]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; nucleocytoplasmic transport [GO:0006913]; pigmentation [GO:0043473]; placenta development [GO:0001890]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]; response to estrogen [GO:0043627]; response to insulin [GO:0032868]; response to interferon-gamma [GO:0034341]; response to interleukin-1 [GO:0070555]; response to interleukin-11 [GO:0071105]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-6 [GO:0070741]; response to interleukin-9 [GO:0071104]; response to lipopolysaccharide [GO:0032496]; response to parathyroid hormone [GO:0071107]; response to transforming growth factor beta [GO:0071559]; SMAD protein signal transduction [GO:0060395]; spongiotrophoblast layer development [GO:0060712]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]; co-SMAD binding [GO:0070410]; LBD domain binding [GO:0050693]; protein C-terminus binding [GO:0008022]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]...
chromatin binding [GO:0003682]; co-SMAD binding [GO:0070410]; LBD domain binding [GO:0050693]; protein C-terminus binding [GO:0008022]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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