DegronMD - Q9BQE4(SELENOS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S140G	SIDM00584	Osteosarcoma	GDSC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation blocking phosphorylation signal	0.6944
p.S140G	SIDM00457	Plasma Cell Myeloma	GDSC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation blocking phosphorylation signal	0.6944
p.S140G	SIDM00260	Gastric Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation blocking phosphorylation signal	0.6944
p.S140G	SIDM01172	Acute Myeloid Leukemia	GDSC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation blocking phosphorylation signal	0.6944
p.S140G	SIDM00054	Pancreatic Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation blocking phosphorylation signal	0.6944
p.S140G	SIDM01770	Gastric Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation blocking phosphorylation signal	0.6944
p.S140G	SIDM00248	Gastric Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation blocking phosphorylation signal	0.6944
p.G142E	SIDM01691	Chronic Myelogenous Leukemia	GDSC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.3056
p.G145S	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation altering degron motif	0.6993
p.G149R	HARA	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2778
p.R136W	SNU-1040	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons