OVOL2
UniProt ID: Q9BRP0
Entrez ID: 58495
Protein name: Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuro...
FUNCTION: Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos (By similarity). {ECO:0000250|UniProtKB:Q8CIV7, ECO:0000269|PubMed:19700410}.
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GO - Biological processes (BP):
angiogenesis [GO:0001525]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dorsal/ventral pattern formation [GO:0009953]; embryonic digestive tract morphogenesis [GO:0048557]; endocardium formation [GO:0060214]; epidermal cell differentiation [GO:0009913]; heart looping [...
angiogenesis [GO:0001525]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dorsal/ventral pattern formation [GO:0009953]; embryonic digestive tract morphogenesis [GO:0048557]; endocardium formation [GO:0060214]; epidermal cell differentiation [GO:0009913]; heart looping [GO:0001947]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of gene expression [GO:0010629]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by competitive promoter binding [GO:0010944]; neural crest cell migration [GO:0001755]; neural fold formation [GO:0001842]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; regulation of cell cycle [GO:0051726]; regulation of keratinocyte proliferation [GO:0010837]; regulation of SMAD protein signal transduction [GO:0060390]; regulation of transcription by RNA polymerase II [GO:0006357]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion ...
chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]
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GO - Cellular component (CC):
nucleus [GO:0005634]...
nucleus [GO:0005634]
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OVOL2
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Kaplan plot for OVOL2 in
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*NOTE: the Kaplan plots were collected from OncoLnc