DegronMD - Q9BRQ0(PYGO2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A111T	TCGA-D1-A167	UCEC	TCGA	PPGY	ITCH	115:118	Mutation rewiring degron network	0.2222
p.A111T	DO40978	UCEC	ICGC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.2222
p.G108W	TCGA-EE-A2A0	SKCM	TCGA	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1389
p.G108W	DO37439	SKCM	ICGC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1389
p.P116S	TCGA-GV-A3QI	BLCA	TCGA	PPGY	ITCH	115:118	Mutation altering degron motif	0.6752
p.P116S	DO470	BLCA	ICGC	PPGY	ITCH	115:118	Mutation altering degron motif	0.6752
p.M110T	DO233823	GACA	ICGC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1944
p.G109D	DO228280	LICA	ICGC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1667
p.Q107R	DO229268	THCA	ICGC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1111
p.G108R	SIDM01240	Melanoma	GDSC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1389
p.G108R	ACH-001002	Skin Cancer	CCLE	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1389
p.G108R	451Lu	skin	COSMIC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1389
p.G109C	SIDM00516	Melanoma	GDSC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1667
p.G109C	SIDM01879	Non-Cancerous	GDSC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1667
p.G109C	ACH-002361	Non-Cancerous	CCLE	PPGY	ITCH	115:118	Mutation rewiring degron network	0.1667
p.R105H	SIDM01451	Pancreatic Carcinoma	GDSC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.0556
p.R105H	ACH-000933	Pancreatic Cancer	CCLE	PPGY	ITCH	115:118	Mutation rewiring degron network	0.0556
p.R105C	SIDM01729	Endometrial Carcinoma	GDSC	PPGY	ITCH	115:118	Mutation rewiring degron network	0.0556
p.R105C	ACH-000909	Endometrial/Uterine Cancer	CCLE	PPGY	ITCH	115:118	Mutation rewiring degron network	0.0556
p.Y117S	U031	kidney	COSMIC	PPGY	ITCH	115:118	Mutation altering degron motif	0.712

Kaplan plot for PYGO2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PYGO2

UniProt ID: Q9BRQ0

Entrez ID: 90780

Protein name: Pygopus homolog 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PYGO2 in