DegronMD - Q9BSA4(TTYH2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A515T	TCGA-AA-3864	COAD	TCGA	PPTY	ITCH	506:509	Mutation rewiring degron network	0.1667
p.P511H	TCGA-AA-3984	COAD	TCGA	PPTY	ITCH	506:509	Mutation rewiring degron network	0.2778
p.P511H	DO9002	COAD	ICGC	PPTY	ITCH	506:509	Mutation rewiring degron network	0.2778
p.P511H	DO45085	LINC	ICGC	PPTY	ITCH	506:509	Mutation rewiring degron network	0.2778
p.S510F	TCGA-D3-A1Q4	SKCM	TCGA	PPTY	ITCH	506:509	Mutation rewiring degron network	0.3056
p.S510F	DO47631	SKCM	ICGC	PPTY	ITCH	506:509	Mutation rewiring degron network	0.3056
p.T508M	TCGA-DX-AB2V	SARC	TCGA	PPTY	ITCH	506:509	Mutation altering degron motif	0.6312
p.P506S	TCGA-EE-A2MD	SKCM	TCGA	PPTY	ITCH	506:509	Mutation altering degron motif	0.6752
p.P506S	TCGA-QB-AA9O	SKCM	TCGA	PPTY	ITCH	506:509	Mutation altering degron motif	0.6752
p.P506S	SIDM00924	Other Solid Cancers	GDSC	PPTY	ITCH	506:509	Mutation altering degron motif	0.6752
p.P506S	SIDM00847	Rhabdomyosarcoma	GDSC	PPTY	ITCH	506:509	Mutation altering degron motif	0.6752
p.P506S	ACH-000169	Sarcoma	CCLE	PPTY	ITCH	506:509	Mutation altering degron motif	0.6752
p.P506S	ACH-000867	Lung Cancer	CCLE	PPTY	ITCH	506:509	Mutation altering degron motif	0.6752
p.P506S	RD	soft tissue	COSMIC	PPTY	ITCH	506:509	Mutation altering degron motif	0.6752
p.P506S	ChaGo-K-1	lung	COSMIC	PPTY	ITCH	506:509	Mutation altering degron motif	0.6752
p.M513I	DO48438	BLCA	ICGC	PPTY	ITCH	506:509	Mutation rewiring degron network	0.2222
p.P506L	DO230329	COCA	ICGC	PPTY	ITCH	506:509	Mutation altering degron motif	0.7582
p.P506L	DO233115	GACA	ICGC	PPTY	ITCH	506:509	Mutation altering degron motif	0.7582
p.P506L	SIDM00847	Rhabdomyosarcoma	GDSC	PPTY	ITCH	506:509	Mutation altering degron motif	0.7582
p.P506L	SIDM00534	Colorectal Carcinoma	GDSC	PPTY	ITCH	506:509	Mutation altering degron motif	0.7582
p.P506L	ACH-000169	Sarcoma	CCLE	PPTY	ITCH	506:509	Mutation altering degron motif	0.7582
p.P506L	ACH-000986	Colon/Colorectal Cancer	CCLE	PPTY	ITCH	506:509	Mutation altering degron motif	0.7582
p.P506L	HT-115	large intestine	COSMIC	PPTY	ITCH	506:509	Mutation altering degron motif	0.7582
p.P506L	RD	soft tissue	COSMIC	PPTY	ITCH	506:509	Mutation altering degron motif	0.7582
p.G501R	SIDM00773	Non-Cancerous	GDSC	PPTY	ITCH	506:509	Mutation rewiring degron network	0.1944
p.G501R	SIDM01653	Non-Cancerous	GDSC	PPTY	ITCH	506:509	Mutation rewiring degron network	0.1944
p.G501R	SIDM00207	Glioblastoma	GDSC	PPTY	ITCH	506:509	Mutation rewiring degron network	0.1944
p.G501R	SIDM00774	Breast Carcinoma	GDSC	PPTY	ITCH	506:509	Mutation rewiring degron network	0.1944

Kaplan plot for TTYH2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTYH2

UniProt ID: Q9BSA4

Entrez ID: 94015

Protein name: Protein tweety homolog 2 (hTTY2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTYH2 in