DegronMD - Q9BT40(INPP5K)

GO - Biological processes (BP): actin cytoskeleton organization [GO:0030036]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hormone stimulus [GO:0032870]; cellular response to insulin stimulus [GO:0032869]; cellular response to tumor necrosis factor [GO:0071356]; dephosphorylation [GO:0016311]; glucose homeostasis [GO:0042593]; G protein-coupled receptor signaling pathway [GO:0007186]; inositol phosphate dephosphorylation [GO:0046855]; in utero embryonic development [GO:0001701]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of glucose transmembrane transport [GO:0010829]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of transcription, DNA-templated [GO:0045892]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of renal water transport [GO:2001153]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of urine volume [GO:0035810]; protein localization to plasma membrane [GO:0072659]; regulation of glycogen biosynthetic process [GO:0005979]; ruffle assembly [GO:0097178] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R240S	DO229019	LICA	ICGC	PPTY	ITCH	244:247	Mutation rewiring degron network	0.2222
p.L238P	DO42033	UCEC	ICGC	PPTY	ITCH	244:247	Mutation rewiring degron network	0.1667
p.P244S	SIDM01148	Plasma Cell Myeloma	GDSC	PPTY	ITCH	244:247	Mutation altering degron motif	0.6752
p.P244S	ACH-000050	Myeloma	CCLE	PPTY	ITCH	244:247	Mutation altering degron motif	0.6752
p.P244S	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	244:247	Mutation altering degron motif	0.6752
p.S239F	HCC2157	breast	COSMIC	PPTY	ITCH	244:247	Mutation rewiring degron network	0.1944
p.T241M	JIMT-1	breast	COSMIC	PPTY	ITCH	244:247	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INPP5K

UniProt ID: Q9BT40

Entrez ID: 51763

Protein name: Inositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Skeletal muscle and kidney-enriched inositol phosphatase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INPP5K in