DegronMD - Q9BUF7(CRB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V39A	TCGA-A8-A07C	BRCA	TCGA	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2778
p.V39A	DO4713	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2778
p.T44I	TCGA-AJ-A3EK	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7078
p.T44I	DO41584	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7078
p.S48C	TCGA-CR-7388	HNSC	TCGA	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.25
p.S48C	DO14284	HNSC	ICGC	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.25
p.A33V	TCGA-VQ-A8P2	STAD	TCGA	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1111
p.A33V	DO51761	STAD	ICGC	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1111
p.R53C	DO48416	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1111
p.A33S	DO229037	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1111
p.R53H	SIDM00542	Glioblastoma	GDSC	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1111
p.R53H	D-392MG	central nervous system	COSMIC	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1111
p.D49N	SIDM01480	Ovarian Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons