DegronMD - Q9BUN1(MENT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q144K	TCGA-80-5608	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.Q144K	DO23693	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.G133E	TCGA-BF-A3DL	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6087
p.G133E	DO51238	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6087
p.P129L	TCGA-BS-A0UM	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.25
p.P129L	DO43065	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.25
p.N130T	TCGA-CA-6718	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2778
p.N130T	DO7801	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2778
p.S136N	TCGA-DF-A2KU	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7069
p.S136N	DO223286	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7069
p.S135F	TCGA-ZF-AA51	BLCA	TCGA	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7982
p.S135F	DO219093	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7982
p.T137K	DO222629	BTCA	ICGC	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.S136R	DO50684	ORCA	ICGC	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7427
p.S136I	DO50734	ORCA	ICGC	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7341
p.A132T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7139

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons