DegronMD - Q9BV44(THUMPD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R484H	TCGA-AX-A3G8	UCEC	TCGA	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.3056
p.R484H	DO41014	UCEC	ICGC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.3056
p.R484H	SIDM01176	B-Lymphoblastic Leukemia	GDSC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.3056
p.R484H	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.3056
p.L475F	TCGA-CV-A6K2	HNSC	TCGA	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.0556
p.L475F	DO52079	HNSC	ICGC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.0556
p.V490A	TCGA-FI-A2D5	UCEC	TCGA	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.6936
p.V490A	DO41331	UCEC	ICGC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.6936
p.T485A	TCGA-HU-A4GX	STAD	TCGA	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.6028
p.T485A	DO47757	STAD	ICGC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.6028
p.H491N	TCGA-KQ-A41N	BLCA	TCGA	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.6312
p.H491N	DO223588	BLCA	ICGC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.6312
p.I483T	TCGA-L5-A8NH	ESCA	TCGA	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.2778
p.Q487E	TCGA-XF-A9T8	BLCA	TCGA	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.5633
p.Q487E	DO51927	BLCA	ICGC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.5633
p.P492S	DO11854	GBM	ICGC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.6752
p.T501A	DO35442	PACA	ICGC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation blocking phosphorylation signal	0.5556
p.V481I	SIDM00373	Endometrial Carcinoma	GDSC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.2222
p.V481I	ACH-000974	Endometrial/Uterine Cancer	CCLE	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.2222
p.V481I	ACH-002026	Endometrial/Uterine Cancer	CCLE	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.2222
p.V481I	SNG-M	endometrium	COSMIC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.2222
p.L482V	SIDM00588	Oral Cavity Carcinoma	GDSC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.25
p.L482V	HSC-4	upper aerodigestive tract	COSMIC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation rewiring degron network	0.25
p.P492L	SIDM01174	Cervical Carcinoma	GDSC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.7582
p.P492L	SW756	cervix	COSMIC	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.7582
p.A488G	ACH-001389	Breast Cancer	CCLE	TPQAFVHPS	DEG_SIAH_1	485:493	Mutation altering degron motif	0.754

Kaplan plot for THUMPD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THUMPD3

UniProt ID: Q9BV44

Entrez ID: 25917

Protein name: tRNA (guanine(6)-N2)-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THUMPD3 in