DegronMD - Q9BWQ6(YIPF2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T22I	TCGA-EB-A6QZ	SKCM	TCGA	AATTS	DEG_SPOP_SBC_1	25:29	Mutation blocking phosphorylation signal	0.6944
p.T22I	DO48626	SKCM	ICGC	AATTS	DEG_SPOP_SBC_1	25:29	Mutation blocking phosphorylation signal	0.6944
p.S29T	TCGA-EI-6882	READ	TCGA	AATTS	DEG_SPOP_SBC_1	25:29	Mutation altering degron motif	0.6005
p.S29T	DO36531	READ	ICGC	AATTS	DEG_SPOP_SBC_1	25:29	Mutation altering degron motif	0.6005
p.T22N	DO229035	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	25:29	Mutation blocking phosphorylation signal	0.6944
p.A20V	SIDM01090	Colorectal Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1944
p.A20V	ACH-000943	Colon/Colorectal Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1944
p.A20V	RKO	large intestine	COSMIC	AATTS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1944
p.A15T	SIDM00217	Colorectal Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0556
p.A15T	ACH-000999	Colon/Colorectal Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0556
p.A15T	SNU-1040	large intestine	COSMIC	AATTS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons