DegronMD - Q9BX10(GTPBP2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P39L	TCGA-4Z-AA7Y	BLCA	TCGA	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.P39L	DO51867	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.V21A	DO229005	COCA	ICGC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.V21A	DO229216	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.V21A	SIDM00231	Kidney Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.V21A	SIDM00054	Pancreatic Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.V21A	SIDM00214	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.S33C	DO229253	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation altering degron motif	0.8652
p.S32N	DO229211	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation altering degron motif	0.7069
p.K43E	DO229229	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation substituting flanking lysine	0.1944
p.G22S	SIDM01144	Gastric Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1111
p.G22S	ACH-000303	Gastric Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1111
p.R33G	NCI-H1703	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	30:34	Mutation altering degron motif	0.7568

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons