DegronMD - Q9BX70(BTBD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G152R	TCGA-13-1506	OV	TCGA	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.25
p.G152R	DO27993	OV	ICGC	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.25
p.A148V	TCGA-D1-A0ZS	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1389
p.A148V	DO43626	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1389
p.M149V	TCGA-EP-A26S	LIHC	TCGA	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1667
p.M149V	DO22854	LIHC	ICGC	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1667
p.D165E	DO228952	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1667
p.A169D	DO228976	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0556
p.A169S	DO232838	NACA	ICGC	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0556
p.T157I	SIDM00672	Hepatocellular Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.7078
p.T157I	ACH-000625	Liver Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.7078
p.T157I	Hep_3B2_1-7	NS	COSMIC	ATTST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.7078
p.M149I	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1667
p.M149I	ACH-002222	Leukemia	CCLE	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1667
p.M149I	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons