DegronMD - Q9BXM0(PRX)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P575L	TCGA-19-5956	GBM	TCGA	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.1111
p.P575L	DO13863	GBM	ICGC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.1111
p.P1450L	TCGA-37-A5EL	LUSC	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.0833
p.P1450L	DO223718	LUSC	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.0833
p.R187C	TCGA-42-2593	OV	TCGA	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8301
p.R187C	DO28329	OV	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8301
p.A1254P	TCGA-68-8251	LUSC	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.25
p.A1254P	DO26858	LUSC	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.25
p.R1434W	TCGA-AM-5821	COAD	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.8634
p.R1434W	DO8240	COAD	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.8634
p.A1252T	TCGA-AX-A062	UCEC	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.3056
p.A1252T	DO40906	UCEC	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.3056
p.A1252T	ACH-000985	Colon/Colorectal Cancer	CCLE	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.3056
p.R1434Q	TCGA-AX-A3G9	UCEC	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.7329
p.R1434Q	DO41241	UCEC	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.7329
p.R1436W	TCGA-BR-8285	STAD	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.7523
p.R1436W	DO38479	STAD	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.7523
p.A1233V	TCGA-BR-A4QL	STAD	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0556
p.A1233V	DO38723	STAD	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0556
p.E561Q	TCGA-C8-A132	BRCA	TCGA	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation altering degron motif	0.5633
p.E561Q	DO1468	BRCA	ICGC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation altering degron motif	0.5633
p.R1375L	TCGA-D3-A2JL	SKCM	TCGA	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation altering degron motif	0.8428
p.R1375L	DO47278	SKCM	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation altering degron motif	0.8428
p.P1450Q	TCGA-D6-8568	HNSC	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.0833
p.P1450Q	DO14388	HNSC	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.0833
p.P178T	TCGA-DD-A73D	LIHC	TCGA	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1111
p.P178T	DO48528	LIHC	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1111
p.P1438S	TCGA-DK-A6AW	BLCA	TCGA	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.5641
p.P1438S	DO48566	BLCA	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.5641
p.A1385T	TCGA-E6-A2P9	UCEC	TCGA	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.25
p.A1385T	DO43714	UCEC	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.25
p.G1251W	TCGA-EE-A3AA	SKCM	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.6714
p.G1251W	DO37571	SKCM	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.6714
p.E561K	TCGA-EK-A2RA	CESC	TCGA	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation altering degron motif	0.591
p.E561K	DO51601	CESC	ICGC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation altering degron motif	0.591
p.R1371W	TCGA-ER-A19P	SKCM	TCGA	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.25
p.R1371W	DO34600	PACA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.25
p.R1371W	DO47623	SKCM	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.25
p.R1391Q	TCGA-FU-A3HZ	CESC	TCGA	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.0833
p.R1391Q	DO6308	CESC	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.0833
p.G1257V	TCGA-G9-6377	PRAD	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1667
p.G1257V	DO36348	PRAD	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1667
p.A1237T	TCGA-SW-A7EA	STAD	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1667
p.A1237T	DO51749	STAD	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1667
p.G1234D	DO222404	BTCA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0833
p.P557T	DO222427	BTCA	ICGC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.3056
p.R1373Q	DO222436	BTCA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.3056
p.R1373Q	DO229376	BTCA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.3056
p.R1373Q	DO233712	GACA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.3056
p.E200K	DO8264	COAD	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1667
p.R194H	DO230312	COCA	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7133
p.R1370H	DO234366	ESAD	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.2222
p.R1370H	DO233882	GACA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.2222
p.E1235K	DO233183	GACA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1111
p.E1235K	SIDM00679	Cervical Carcinoma	GDSC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1111
p.E1235K	ACH-001525	Cervical Cancer	CCLE	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1111
p.E1235K	HT-3	cervix	COSMIC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1111
p.R185H	DO233089	GACA	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.3056
p.R185H	SIDM00967	Ovarian Carcinoma	GDSC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.3056
p.G1257E	DO233780	GACA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1667
p.R1380C	DO233869	GACA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation altering degron motif	0.719
p.L1250R	DO228187	LICA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.8428
p.S560P	DO228912	LICA	ICGC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation altering degron motif	0.5641
p.L548M	DO228948	LICA	ICGC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.0556
p.A1252D	DO229015	LICA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.3056
p.A1233E	DO229025	LICA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0556
p.R1377C	DO229036	LICA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation altering degron motif	0.719
p.S1387F	DO220891	MELA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.1944
p.S1387F	DO222542	MELA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.1944
p.G1424W	DO46374	OV	ICGC	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.0833
p.R187H	DO33091	PACA	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8244
p.A1367T	DO232761	PBCA	ICGC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.1389
p.A1254T	DO232761	PBCA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.25
p.R192Q	DO51953	PRAD	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.6218
p.P180S	DO47331	SKCM	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1667
p.P180L	DO38535	STAD	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1667
p.A199V	DO229211	THCA	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.R1380H	SIDM02069	Colorectal Carcinoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation altering degron motif	0.7133
p.R1380H	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation altering degron motif	0.7133
p.R1370S	SIDM00683	Prostate Carcinoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.2222
p.R1370S	SIDM01397	Melanoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.2222
p.R1370S	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.2222
p.R1370S	LNCaP-Clone-FGC	prostate	COSMIC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.2222
p.R1370C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.2222
p.R1370C	ACH-000981	Leukemia	CCLE	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.2222
p.R1370C	DND-41	haematopoietic and lymphoid tissue	COSMIC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.2222
p.R1436Q	SIDM00078	Oral Cavity Carcinoma	GDSC	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.6218
p.R1436Q	ACH-000228	Head and Neck Cancer	CCLE	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.6218
p.R1436Q	BICR31	upper aerodigestive tract	COSMIC	LRVRLPSVG	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.6218
p.V551M	SIDM00501	Oral Cavity Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.1389
p.V551M	SIDM00221	Melanoma	GDSC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.1389
p.V551M	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.1389
p.V551M	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.1389
p.V551M	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.1389
p.V551M	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.1389
p.R194C	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	RRLQLPRLR	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.719
p.S1387C	SIDM00893	Breast Carcinoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.1944
p.S1387C	ACH-000536	Breast Cancer	CCLE	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.1944
p.S1387C	BT-20	breast	COSMIC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.1944
p.R1391W	SIDM00420	Bladder Carcinoma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.0833
p.R1391W	ACH-000566	Bladder Cancer	CCLE	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.0833
p.R1391W	SW1710	urinary tract	COSMIC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.0833
p.R1373G	SIDM00006	Other Solid Cancers	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.3056
p.R1373G	ACH-001552	Skin Cancer	CCLE	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.3056
p.R1373G	MCC26	skin	COSMIC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.3056
p.V564M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation altering degron motif	0.7208
p.V564M	ACH-002222	Leukemia	CCLE	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation altering degron motif	0.7208
p.V564M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation altering degron motif	0.7208
p.P557Q	SIDM00220	Ovarian Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.3056
p.P557Q	ACH-000962	Ovarian Cancer	CCLE	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.3056
p.P557Q	OC-314	ovary	COSMIC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation rewiring degron network	0.3056
p.A563V	SIDM01608	Endometrial Carcinoma	GDSC	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation altering degron motif	0.5825
p.A563V	ACH-000990	Endometrial/Uterine Cancer	CCLE	EVSEVAVPEV	DEG_COP1_1	558:567	Mutation altering degron motif	0.5825
p.G1372V	SIDM01577	Plasma Cell Myeloma	GDSC	VRVRLPRVG	DEG_APCC_DBOX_1	1374:1382	Mutation rewiring degron network	0.2778
p.T1238A	SIDM01611	Endometrial Carcinoma	GDSC	LRLKLPTLG	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRX

UniProt ID: Q9BXM0

Entrez ID: 57716

Protein name: Periaxin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRX in