ERVK-6
UniProt ID: Q9BXR3
Entrez ID:
Protein name: Endogenous retrovirus group K member 6 Pol protein (HERV-K(C7) Pol protein) (HERV-K(HML-2.HOM) Pol protein) (HERV-K108 Pol protein) (HERV-K_7p22.1 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nucl...
FUNCTION: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.
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GO - Biological processes (BP):
DNA integration [GO:0015074]; DNA recombination [GO:0006310]...
DNA integration [GO:0015074]; DNA recombination [GO:0006310]
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GO - Molecular function (MF):
DNA binding [GO:0003677]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; RNA stem-loop binding [GO:0035613]; zinc ion binding [GO:0008270]...
DNA binding [GO:0003677]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; RNA stem-loop binding [GO:0035613]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
...
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ERVK-6
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*NOTE: the Kaplan plots were collected from OncoLnc