DegronMD - Q9BY19(MS4A8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I246M	TCGA-49-AARE	LUAD	TCGA	PPSY	ITCH	239:242	Mutation rewiring degron network	0.2222
p.I246M	DO218922	LUAD	ICGC	PPSY	ITCH	239:242	Mutation rewiring degron network	0.2222
p.I246N	TCGA-E2-A1B0	BRCA	TCGA	PPSY	ITCH	239:242	Mutation rewiring degron network	0.2222
p.I246N	DO4581	BRCA	ICGC	PPSY	ITCH	239:242	Mutation rewiring degron network	0.2222
p.P239Q	TCGA-FS-A1ZF	SKCM	TCGA	PPSY	ITCH	239:242	Mutation altering degron motif	0.7035
p.P239Q	DO38039	SKCM	ICGC	PPSY	ITCH	239:242	Mutation altering degron motif	0.7035
p.P233Q	TCGA-G7-6797	KIRP	TCGA	PPSY	ITCH	239:242	Mutation rewiring degron network	0.1667
p.P233Q	DO20917	KIRP	ICGC	PPSY	ITCH	239:242	Mutation rewiring degron network	0.1667
p.S244R	TCGA-NJ-A4YI	LUAD	TCGA	PPSY	ITCH	239:242	Mutation rewiring degron network	0.2778
p.S244R	DO218942	LUAD	ICGC	PPSY	ITCH	239:242	Mutation rewiring degron network	0.2778
p.E245D	TCGA-XF-AAMG	BLCA	TCGA	PPSY	ITCH	239:242	Mutation rewiring degron network	0.25
p.E245D	DO219049	BLCA	ICGC	PPSY	ITCH	239:242	Mutation rewiring degron network	0.25
p.K250T	DO50406	ESAD	ICGC	PPSY	ITCH	239:242	Mutation substituting flanking lysine	0.2222
p.Q247K	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	239:242	Mutation rewiring degron network	0.1944
p.Q247K	ACH-001233	Lung Cancer	CCLE	PPSY	ITCH	239:242	Mutation rewiring degron network	0.1944
p.Q247K	VMRC-LCD	lung	COSMIC	PPSY	ITCH	239:242	Mutation rewiring degron network	0.1944
p.P235L	SIDM00850	Gastric Carcinoma	GDSC	PPSY	ITCH	239:242	Mutation rewiring degron network	0.2222
p.P235L	ACH-000880	Gastric Cancer	CCLE	PPSY	ITCH	239:242	Mutation rewiring degron network	0.2222
p.P235L	AGS	stomach	COSMIC	PPSY	ITCH	239:242	Mutation rewiring degron network	0.2222

Kaplan plot for MS4A8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MS4A8

UniProt ID: Q9BY19

Entrez ID: 83661

Protein name: Membrane-spanning 4-domains subfamily A member 8 (Four-span transmembrane protein 4) (Membrane-spanning 4-domains subfamily A member 8B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MS4A8 in