DegronMD - Q9BYH1(SEZ6L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A77T	TCGA-A5-A1OF	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.25
p.A77T	DO42568	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.25
p.A77V	TCGA-D1-A16X	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.25
p.A77V	DO41799	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.25
p.V84A	TCGA-DD-A1EE	LIHC	TCGA	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556
p.V84A	TCGA-DD-A1EF	LIHC	TCGA	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556
p.V84A	DO44915	LIHC	ICGC	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556
p.V84A	DO22857	LIHC	ICGC	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556
p.P70L	TCGA-EE-A2MR	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7582
p.P70L	TCGA-FW-A3R5	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7582
p.P70L	DO37819	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7582
p.P70L	DO37406	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7582
p.E82D	DO229038	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1111
p.E60Q	SIDM01128	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556
p.E60Q	ACH-000767	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556
p.E60Q	NCI-H526	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556
p.N84S	SNU-1040	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556

Kaplan plot for SEZ6L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEZ6L

UniProt ID: Q9BYH1

Entrez ID: 23544

Protein name: Seizure 6-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEZ6L in