DegronMD - Q9BYZ6(RHOBTB2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R721Q	TCGA-60-2698	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7329
p.R721Q	TCGA-CG-5718	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7329
p.R721Q	DO26469	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7329
p.R721Q	DO38340	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7329
p.R704W	TCGA-AJ-A3EK	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0556
p.R704W	TCGA-FP-A9TM	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0556
p.R707C	TCGA-AX-A0J1	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1389
p.R707C	DO41199	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1389
p.E706G	TCGA-B5-A3FA	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1111
p.E706G	DO52402	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1111
p.R704Q	TCGA-BG-A222	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0556
p.R704Q	TCGA-VQ-A8P2	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0556
p.R704Q	DO51761	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0556
p.R704Q	DO42977	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0556
p.P732Q	TCGA-EM-A2CL	THCA	TCGA	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1111
p.P732Q	DO40640	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1111
p.R717W	TCGA-FI-A2D0	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.8634
p.R722C	TCGA-HU-8602	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.8301
p.R722C	DO47829	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.8301
p.S734F	SIDM00217	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.0556
p.S734F	ACH-000999	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.0556
p.S734F	SNU-1040	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.0556
p.R722H	SIDM01608	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.8244
p.R722H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.8244
p.S712F	SNU-1040	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.2778
p.S712F	SNU-1040	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1111
p.S719F	SNU-1040	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.3056
p.S719F	SNU-1040	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.3056
p.R707H	RPMI-2650	upper aerodigestive tract	COSMIC	AASSS	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1389

Kaplan plot for RHOBTB2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RHOBTB2

UniProt ID: Q9BYZ6

Entrez ID: 23221

Protein name: Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RHOBTB2 in