NSD3
UniProt ID: Q9BZ95
Entrez ID: 54904
Protein name: Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:1...
FUNCTION: Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}.
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GO - Biological processes (BP):
chromatin organization [GO:0006325]; histone methylation [GO:0016571]; positive regulation of histone H3-K36 trimethylation [GO:2001255]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]...
chromatin organization [GO:0006325]; histone methylation [GO:0016571]; positive regulation of histone H3-K36 trimethylation [GO:2001255]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]
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GO - Molecular function (MF):
histone-lysine N-methyltransferase activity [GO:0018024]; histone methyltransferase activity (H3-K36 specific) [GO:0046975]; metal ion binding [GO:0046872]; transcription regulator activator activity [GO:0140537]...
histone-lysine N-methyltransferase activity [GO:0018024]; histone methyltransferase activity (H3-K36 specific) [GO:0046975]; metal ion binding [GO:0046872]; transcription regulator activator activity [GO:0140537]
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GO - Cellular component (CC):
chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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NSD3
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*NOTE: the Kaplan plots were collected from OncoLnc