DegronMD - Q9BZE9(ASPSCR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S265Y	TCGA-2W-A8YY	CESC	TCGA	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.8231
p.S265Y	DO223732	CESC	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.8231
p.P261H	TCGA-A5-A0G2	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.7694
p.P261H	DO41235	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.7694
p.P261S	TCGA-CD-A4MG	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.6752
p.P261S	DO48009	STAD	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.6752
p.G253V	TCGA-D3-A2JK	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1111
p.G253V	DO37619	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1111
p.S272F	TCGA-EE-A3JA	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1389
p.S272F	DO220891	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1389
p.S272F	DO47625	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1389
p.K271Q	TCGA-FI-A2D5	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation substituting flanking lysine	0.2778
p.K271Q	DO41331	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation substituting flanking lysine	0.2778
p.G254V	TCGA-QK-A8ZA	HNSC	TCGA	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1389
p.G254V	DO52099	HNSC	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1389
p.G254V	DO46478	OV	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1389
p.L252Q	DO228483	BRCA	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.L252Q	DO229013	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.L252Q	DO229016	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.L252Q	DO229005	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.L252Q	DO229505	LAML	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.L252Q	DO229047	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.L252Q	DO231207	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.P270L	DO227646	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1944
p.L269F	DO229038	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.2222
p.F267L	SNU-81	large intestine	COSMIC	PLTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.2778

Kaplan plot for ASPSCR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASPSCR1

UniProt ID: Q9BZE9

Entrez ID: 79058

Protein name: Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASPSCR1 in