DegronMD - Q9BZF3(OSBPL6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S203F	TCGA-06-5416	GBM	TCGA	PSTST	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7982
p.S203F	TCGA-A5-A0G2	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7982
p.S203F	DO10880	GBM	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7982
p.S203F	DO41235	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7982
p.S32I	TCGA-2W-A8YY	CESC	TCGA	ASSST	DEG_SPOP_SBC_1	22:26	Mutation blocking phosphorylation signal	0.6111
p.S32I	DO223732	CESC	ICGC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation blocking phosphorylation signal	0.6111
p.P209Q	TCGA-37-3789	LUSC	TCGA	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1944
p.P209Q	DO26743	LUSC	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1944
p.H197Y	TCGA-3N-A9WD	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.H197Y	DO51235	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.S28Y	TCGA-AJ-A5DW	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.S28Y	DO50075	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.S214Y	TCGA-AP-A056	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.S214Y	DO43971	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.P200S	TCGA-BF-AAP7	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.6752
p.P200S	DO219472	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.6752
p.D193Y	TCGA-BR-8680	STAD	TCGA	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.D193Y	DO47769	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.S208L	TCGA-BR-8687	STAD	TCGA	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.S208L	DO47801	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.H12N	TCGA-CN-6010	HNSC	TCGA	ASSST	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0556
p.H12N	DO14766	HNSC	ICGC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0556
p.H12Y	TCGA-EE-A2MR	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0556
p.H12Y	DO37819	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0556
p.S35I	TCGA-EY-A1GI	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	22:26	Mutation blocking phosphorylation signal	0.5278
p.S35I	TCGA-EY-A1GI	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	43:47	Mutation blocking phosphorylation signal	0.5556
p.S35I	DO41211	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation blocking phosphorylation signal	0.5278
p.S35I	DO41211	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	43:47	Mutation blocking phosphorylation signal	0.5556
p.E206Q	TCGA-IG-A3Y9	ESCA	TCGA	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.A22S	TCGA-J2-A4AD	LUAD	TCGA	ASSST	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7588
p.A22S	DO23915	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7588
p.I198M	TCGA-R6-A8W5	ESCA	TCGA	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.T202A	DO234227	ESAD	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7139
p.R53Q	DO229346	LAML	ICGC	ASSST	DEG_SPOP_SBC_1	43:47	Mutation rewiring degron network	0.1667
p.A194S	DO229037	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1667
p.T14I	DO229046	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.S28F	DO220872	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.P17L	DO220885	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1944
p.S190L	DO220902	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation blocking phosphorylation signal	0.5
p.R13Q	SIDM00927	Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation substituting flanking lysine	0.1944
p.R13Q	NCI-H510A	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation substituting flanking lysine	0.1944
p.E40G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	43:47	Mutation rewiring degron network	0.25
p.E40G	DND-41	haematopoietic and lymphoid tissue	COSMIC	ASSST	DEG_SPOP_SBC_1	43:47	Mutation rewiring degron network	0.25
p.R13W	SIDM00257	Neuroblastoma	GDSC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation substituting flanking lysine	0.1944
p.R13W	SIDM01617	Endometrial Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation substituting flanking lysine	0.1944
p.R13W	NB13	autonomic ganglia	COSMIC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation substituting flanking lysine	0.1944
p.T202R	SIDM01682	Gastric Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7876
p.R13G	SIDM01451	Pancreatic Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation substituting flanking lysine	0.1944
p.E19G	DND-41	haematopoietic and lymphoid tissue	COSMIC	ASSST	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.A46S	NCI-H650	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	43:47	Mutation altering degron motif	0.7588
p.P211S	ACN	autonomic ganglia	COSMIC	PSTST	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389

Kaplan plot for OSBPL6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OSBPL6

UniProt ID: Q9BZF3

Entrez ID: 114880

Protein name: Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OSBPL6 in