DegronMD - Q9BZJ0(CRNKL1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R274Q	TCGA-B5-A11E	UCEC	TCGA	DYR	CBL_MET	272:274	Mutation altering degron motif	0.7329
p.R274Q	DO41644	UCEC	ICGC	DYR	CBL_MET	272:274	Mutation altering degron motif	0.7329
p.A283T	TCGA-BR-8487	STAD	TCGA	DYR	CBL_MET	272:274	Mutation rewiring degron network	0.0833
p.A283T	TCGA-ZJ-AAXA	CESC	TCGA	DYR	CBL_MET	272:274	Mutation rewiring degron network	0.0833
p.A283T	DO219752	CESC	ICGC	DYR	CBL_MET	272:274	Mutation rewiring degron network	0.0833
p.A283T	DO47867	STAD	ICGC	DYR	CBL_MET	272:274	Mutation rewiring degron network	0.0833
p.R262Q	TCGA-F4-6570	COAD	TCGA	DYR	CBL_MET	272:274	Mutation rewiring degron network	0.0556
p.R262Q	DO10443	COAD	ICGC	DYR	CBL_MET	272:274	Mutation rewiring degron network	0.0556
p.A268V	DO10172	COAD	ICGC	DYR	CBL_MET	272:274	Mutation rewiring degron network	0.2222
p.Y265H	SIDM00095	Glioblastoma	GDSC	DYR	CBL_MET	272:274	Mutation blocking phosphorylation signal	0.5833
p.Y265H	SNB75	central nervous system	COSMIC	DYR	CBL_MET	272:274	Mutation blocking phosphorylation signal	0.5833
p.S283P	ACH-000999	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	272:274	Mutation rewiring degron network	0.0833
p.S283P	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	272:274	Mutation rewiring degron network	0.0833

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons