DegronMD - Q9BZJ3(TPSD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P181T	TCGA-73-7498	LUAD	TCGA	PPPY	ITCH	177:180	Mutation rewiring degron network	0.3056
p.P181T	DO23802	LUAD	ICGC	PPPY	ITCH	177:180	Mutation rewiring degron network	0.3056
p.V174L	TCGA-B8-A54K	KIRC	TCGA	PPPY	ITCH	177:180	Mutation rewiring degron network	0.25
p.V174L	DO219234	KIRC	ICGC	PPPY	ITCH	177:180	Mutation rewiring degron network	0.25
p.V170M	TCGA-D8-A1Y1	BRCA	TCGA	PPPY	ITCH	177:180	Mutation rewiring degron network	0.1389
p.V170M	DO1398	BRCA	ICGC	PPPY	ITCH	177:180	Mutation rewiring degron network	0.1389
p.V170M	ACH-001145	Ovarian Cancer	CCLE	PPPY	ITCH	177:180	Mutation rewiring degron network	0.1389
p.P181S	TCGA-EO-A22U	UCEC	TCGA	PPPY	ITCH	177:180	Mutation rewiring degron network	0.3056
p.P181S	DO43755	UCEC	ICGC	PPPY	ITCH	177:180	Mutation rewiring degron network	0.3056
p.V189I	TCGA-K4-A4AB	BLCA	TCGA	PPPY	ITCH	177:180	Mutation rewiring degron network	0.0833
p.V189I	DO44039	BLCA	ICGC	PPPY	ITCH	177:180	Mutation rewiring degron network	0.0833
p.N173D	DO229010	COCA	ICGC	PPPY	ITCH	177:180	Mutation rewiring degron network	0.2222
p.N173D	DO229005	COCA	ICGC	PPPY	ITCH	177:180	Mutation rewiring degron network	0.2222
p.N173D	DO229224	THCA	ICGC	PPPY	ITCH	177:180	Mutation rewiring degron network	0.2222
p.E184V	SIDM00518	Mesothelioma	GDSC	PPPY	ITCH	177:180	Mutation rewiring degron network	0.2222
p.P179T	SIDM00667	Other Sarcomas	GDSC	PPPY	ITCH	177:180	Mutation altering degron motif	0.5919
p.P179T	SIDM00780	Colorectal Carcinoma	GDSC	PPPY	ITCH	177:180	Mutation altering degron motif	0.5919
p.A190T	KNS-62	lung	COSMIC	PPPY	ITCH	177:180	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons