DegronMD - Q9BZR8(BCL2L14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V194M	TCGA-06-5416	GBM	TCGA	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.2778
p.V194M	DO10880	GBM	ICGC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.2778
p.E205V	TCGA-36-2530	OV	TCGA	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1944
p.E205V	DO28000	OV	ICGC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1944
p.F188V	TCGA-44-A4SS	LUAD	TCGA	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.F188V	DO24227	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.S200C	TCGA-DO-A2HM	THCA	TCGA	VASSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.7541
p.S200C	TCGA-G2-AA3D	BLCA	TCGA	VASSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.7541
p.S200C	DO51884	BLCA	ICGC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.7541
p.S200C	DO40616	THCA	ICGC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.7541
p.Q207H	TCGA-EO-A3AV	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1389
p.Q207H	DO52412	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1389
p.V196E	SIDM00845	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.7693
p.V196E	SIDM01140	Ovarian Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.7693
p.I208M	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.I208M	ACH-002101	Lung Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.I208M	EMC-BAC-1	lung	COSMIC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.V196I	SIDM00892	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.7076
p.I186V	NCI-H226	lung	COSMIC	VASSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0556

Kaplan plot for BCL2L14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCL2L14

UniProt ID: Q9BZR8

Entrez ID: 79370

Protein name: Apoptosis facilitator Bcl-2-like protein 14 (Bcl2-L-14) (Apoptosis regulator Bcl-G)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCL2L14 in